Skip to main content
Fig. 1 | BMC Medicine

Fig. 1

From: Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver diseases

Fig. 1

Hepatic expression of genes related to ductular reaction in patients with chronic liver disease (cohort i). Fifty-seven livers from patients with various stages of liver fibrosis (fibrosis stages F0–F4) were analyzed (cohort i). ac Relative hepatic expression of keratins 19, 7, and 23 (K19/K7/K23), compared to RPLP0. Average K7/19/23 expression in control subjects was arbitrarily set as 1 and all other levels represent a ratio. d, e Spearman’s correlation coefficient quantifies the relationship between the hepatic expression of K19 mRNA and K7 (d) or K23 (e). f K19 protein levels were determined by immunoblotting and tubulin was used as a loading control. The relative band intensity (lower panel) was quantified using ImageJ. *P < .05, **P < .01, ***P < .001, ****P < .0001

Back to article page