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Fig. 2 | BMC Medicine

Fig. 2

From: Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver diseases

Fig. 2

Serum CYFRA21-1 as an indicator of clinically significant portal hypertension (CSPH) and transplant-free liver-related survival in patients with portal hypertension due to advanced chronic liver disease (ACLD; cohort ii). Three hundred thirty-three patients (median follow-up of 22 months) were analyzed (cohort ii). a Correlation of serum CYFRA21-1 and hepatic venous pressure gradient (HVPG). Data from patients with hepatic decompensation or liver-related death (events) are depicted in red color whereas the data from patients without hepatic decompensation or liver-related death (event-free) are depicted in blue color. b Serum CYFRA21-1 levels in three strata of ACLD patients with HVPG of 6–9 mmHg (no CSPH), 10–15 mmHg, and ≥ 16 mmHg. The serum CYFRA21-1 cut-off of 3.90 ng/mL was used to generate Kaplan-Meier curves (CYFRA21-1 < 3.90 ng/mL in blue, CYFRA21-1 ≥ 3.90 ng/mL in red) for the following outcomes: c the cumulative transplant-free, liver-related survival in the overall cohort and d the cumulative transplant-free, liver-related survival in patients with CSPH (HVPG ≥ 10 mmHg). Unadjusted hazard ratios (HRs) with their 95% confidence intervals [in brackets] and log-rank P values are shown in the corresponding graphs

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