Table 1 Characteristics of the patient cohort with portal hypertension due to advanced chronic liver disease (ACLD), stratified by the presence of clinically significant portal hypertension (CSPH) (cohort ii)
ACLD (n = 333) | No CSPH (n = 53) | CSPH (n = 280) | P value | |
|---|---|---|---|---|
Age (years) | 54 (15) | 55 (14) | 54 (15) | 0.51 |
Male sex (n, %) | 243 (73) | 40 (76) | 203 (73) | .66 |
Alcohol (n, %) | 119 (36) | 6 (11) | 113 (40) | < .001 |
Non-alcoholic fatty liver (n, %) | 28 (8) | 5 (9) | 23 (8) | |
Viral (n, %) | 141 (42) | 38 (72) | 103 (37) | |
Child-Pugh score (points) | 6 (3) | 5 (0) | 7 (4) | < .001 |
MELD score (points) | 10 (5) | 8 (2) | 11 (5) | < .001 |
ALT (U/L) | 41 (51) | 61 (66) | 40 (46) | .001 |
AST (U/L) | 59 (53) | 60 (52) | 58 (53) | .97 |
Bilirubin (mg/dL) | 1.1 (1.1) | 0.6 (0.4) | 1.2 (1.3) | < .001 |
Albumin (g/L) | 36.7 (8.3) | 40.5 (4.2) | 35.7 (7.9) | < .001 |
INR | 1.20 (0.30) | 1.10 (0.18) | 1.30 (0.22) | < .001 |
Creatinine (mg/dL) | 0.77 (0.24) | 0.87 (0.27) | 0.74 (0.23) | .001 |
Platelet count (G/L) | 105 (79) | 152 (63) | 99 (62) | < .001 |
HVPG (mmHg) | 17 (10) | 8 (2) | 18 (7) | < .001 |
CYFRA21-1 (ng/mL) | 4.3 (3.3) | 3.0 (1.5) | 4.6 (3.3) | < .001 |
Liver-related death (n, %) | 70 (21) | 10 (19) | 60 (21) | .68 |
Hepatic decompensation or liver-related death (n, %) | 176 (53) | 19 (36) | 157 (56) | .007 |