Table 3 Characteristics of the patient cohort with cirrhosis due to long-term alcohol misuse included in HCC surveillance programs, stratified by liver-related survival (cohort iii)
Alcoholic cirrhosis (n = 231) | Transplant-free survivors (n = 133) | Non-survivors* (n = 98) | P value | |
|---|---|---|---|---|
Age at cirrhosis diagnosis (years) | 56.5 (12.4) | 56.4 (10.8) | 56.6 (14.9) | .61 |
Male sex | 185 (80.1%) | 105 (78.9%) | 80 (81.6%) | .64 |
BMI (kg/m2) | 27.0 (6.0) | 27.0 (5.9) | 27.5 (7.0) | .07 |
Diabetes mellitus | 70 (30.4%) | 38 (28.6%) | 32 (32.7%) | .50 |
Ascites | 87 (37.4%) | 45 (33.8%) | 42 (42.9%) | .19 |
Hepatic encephalopathy | 23 (10.0%) | 9 (6.8%) | 14 (14.3%) | .056 |
Child-Pugh score (points) | 6 (3) | 6 (3) | 7 (3) | < .001 |
HCC during follow-up | 56 (23.9%) | 9 (6.8%) | 47 (48.0%) | < .001 |
Survival (years) | 5.0 (6.5) | 5.0 (7.3) | 4.8 (5.0) | .78 |
Liver transplantation | 17 (7.4%) | – | 17 (17.5%) | NA |
Liver-related death | 93 (40.4%) | – | 93 (95.9%) | NA |
Death | – | – | 98 (100%) | NA |
HCC-related | 44 (44.9%) | |||
Liver-related | 50 (51.0%) | |||
Extra-hepatic | 4 (4.1%) | |||
ALT (× ULN) | 1.0 (1.0) | 1.0 (1.0) | 1.0 (1.0) | .28 |
AST (× ULN) | 2.0 (1.0) | 2.0 (1.0) | 2.0 (1.5) | .99 |
GGT (× ULN) | 4.0 (6.0) | 4.0 (6.0) | 5.0 (6.0) | .45 |
Bilirubin (μmol/L) | 23.0 (35.5) | 21.0 (31.0) | 33.0 (47.0) | .001 |
Albumin (mg/dL) | 36.3 (10.3) | 39.0 (9.4) | 34.0 (10.1) | .001 |
PT (% of control) | 65.0 (30.5) | 68.0 (27.0) | 57.0 (30.5) | < .001 |
Platelet count (G/L) | 123.5 (74) | 129.0 (83.0) | 114.0 (57.0) | .08 |
CYFRA21-1 (ng/mL) | 5.26 (1.75) | 4.99 (1.81) | 5.58 (1.75) | .008 |