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Table 4 Characteristics of hospitalized patients with decompensated cirrhosis and ascites, stratified by liver-related survival (cohort iv)

From: Serum keratin 19 (CYFRA21-1) links ductular reaction with portal hypertension and outcome of various advanced liver diseases

  Decompensated cirrhosis (n = 280) Transplant-free survivors* at 90 days (n = 192) Non-survivors** at 90 days (n = 88) P value
Age (years) 59 (52–67) 57 (48–64) 63 (55–69) < 0.001
Male sex 206 (74) 142 (74) 64 (73) 0.88
Alcoholic liver disease 220 (79) 158 (82) 62 (70) 0.03
Self-reported alcohol use within the 30 days before admission 128 (46) 91 (47) 37 (42) 0.44
HCC 39 (14) 21 (11) 18 (20) 0.04
SBP 37 (13) 14 (7) 23 (26) < 0.0001
Child-Pugh C 174 (62) 109 (57) 65 (74) < 0.01
MELD score 17 (12–22) 16 (12–20) 22 (14–28) < 0.000001
ACLF 73 (26) 34 (18) 39 (44) < 0.00001
ACLF grade (1/2/3) 40 (55)/20 (27)/13 (18) 24 (71)/9 (26)/1 (3) 16 (41)/11 (28)/12 (31) < 0.01
ALT (μmol L−1 s−1) 0.56 (0.38–0.88) 0.56 (0.38–0.77) 0.58 (0.41–1.16) 0.07
AST (μmol L−1 s−1) 1.07 (0.70–1.86) 1.04 (0.68–1.71) 1.12 (0.73–2.55) 0.14
Bilirubin (μmol L−1) 40 (20–97) 37 (23–87) 78 (24–173) < 0.0001
Albumin (g L−1) 25 (20–29) 24 (20–29) 25 (20–29) 0.90
INR 1.4 (1.2–1.7) 1.4 (1.2–1.7) 1.5 (1.3–1.9) < 0.001
Creatinine (μmol L−1) 95 (64–146) 77 (60–120) 134 (78–182) < 0.000001
Platelet count (nL−1) 127 (81–181) 133 (83–181) 110 (70–162) 0.02
CYFRA21-1 (ng/mL) 5.37 (0.20–11.01) 5.21 (0.20–9.80) 8.94 (1.96–20.53) < 0.0001
  1. Quantitative measures are shown as median (interquartile range) or as an absolute count (n) and relative frequency (%). Abbreviations: HCC hepatocellular carcinoma, SBP spontaneous bacterial peritonitis, MELD model for end-stage liver disease, ACLF acute-on-chronic liver failure, ALT alanine aminotransferase, AST aspartate aminotransferase, INR international normalized ratio. *Including 38 patients who were lost to follow-up after a median of 14 days. **Non-survivors include patients who died (n = 78) or received a liver transplantation (n = 10) within 90 days after study recruitment