Breast cancer risk factors and their effects on survival: a Mendelian randomisation study

Table 2 Effect of nine breast cancer risk factors on breast cancer-specific survival for all breast cancers, estrogen receptor (ER)-positive and ER-negative breast cancers. HR hazard ratio, CI 95% confidence interval, FDR false discovery rate

Risk factor	All				ER-positive				ER-negative
Risk factor	HR	CI	P value	FDR	HR	CI	P value	FDR	HR	CI	P value	FDR
Alcohol consumption (drinks per week)	1.10	0.76–1.60	0.62	0.92	1.12	0.69–1.81	0.65	0.65	0.91	0.42–1.97	0.82	0.90
Body mass index (adult, kg/m²)	1.01	0.81–1.25	0.95	0.95	1.10	0.83–1.45	0.52	0.62	1.14	0.72–1.82	0.57	0.88
Height (adult, m)	0.99	0.89–1.11	0.89	0.95	1.04	0.91–1.21	0.55	0.62	1.08	0.82–1.27	0.88	0.90
Mammographic density (dense vs non-dense area)	0.94	0.75–1.18	0.59	0.92	0.90	0.75–1.08	0.24	0.59	1.12	0.79–1.60	0.52	0.88
Menarche (age at onset)	1.07	0.97–1.18	0.21	0.92	1.06	0.94–1.21	0.34	0.61	1.06	0.86–1.29	0.59	0.88
Menopause (age at onset)	1.01	0.98–1.05	0.49	0.92	1.03	0.98–1.08	0.21	0.59	1.01	0.93–1.08	0.90	0.90
Physical activity (overall physical activity time)	1.06	0.52–2.16	0.87	0.95	1.66	0.48–5.71	0.43	0.62	0.36	0.09–1.54	0.17	0.77
Smoking behaviour (ever vs never)	1.07	0.83–1.38	0.59	0.92	0.82	0.58–1.16	0.26	0.59	1.53	0.92–2.54	0.10	0.77
Type 2 diabetes mellitus (yes vs no)	1.10	1.04–1.18	0.01	0.02	1.09	1.01–1.18	0.04	0.32	1.09	0.97–1.24	0.15	0.88

ISSN: 1741-7015