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Table 2 Intervention model parameters. CrI credible interval

From: Evaluating the next generation of RSV intervention strategies: a mathematical modelling study and cost-effectiveness analysis

 

Parameter

Mean value (95% CI where applicable)

Reference

Palivizumab

 

Delay between administration and protection (days)

Immediate (fixed)

[16]

 ωpal

Average period of protection (days)

150 (fixed)

[16]

 epal

Efficacy on VHR infants (%)

33.8 (0.0–66.6)1

[16]

Long-acting monoclonal antibodies

 

Delay between administration and protection (days)

Immediate (fixed)

[4]

 ωmab

Average period of protection (days)

275 (fixed)

[4]

 eSmab

Efficacy against symptomatic infection (%)

70.1 (52.3–81.0)2

[37]

 eHmab

Efficacy against hospitalisation (%)

78.4 (51.9–90.3)3

[37]

Childhood/elderly vaccine

 dvac

Delay between administration and protection (days)

11.4 (2.8–22.1)4

[38]

 ω

Average period of protection (days)

Same as post-infection immunity (1/ω)

[38]

 evac

Efficacy against all infections (%)

83.0 (75.0–88.0)5

[38]

Novavax vaccine

 d2mat

Average period of protection (days)

133.5 (119.6–146.1)

Same as maternally derived immunity

 eSmat

Efficacy against symptomatic infection (%)

41.4 (4.1–64.2)6

[5]

 eHmat

Efficacy against hospitalisations (%)

53.5 (23.0–71.9)7

[5]

  1. Fitted distributions
  2. 1Gamma (3.7623, 0.0898)
  3. 2W(11.898, 0.732)
  4. 3W(11.611, 0.819)
  5. 4W(2.42, 12.87)
  6. 5W(31.464, 0.845)
  7. 6W(3.327, 0.461)
  8. 7W(5.354, 0.580)