Fig. 4

Ablation of the nSMase2/Smpd3 gene in the mdx genetic background enhances muscle performance. Grip force (a), body weight (b), and average time spent running on the treadmill in wt, mdx, and mdx:Smpd3^+/− (#11: n = 3; #28: n = 9) mice at 12 weeks of age (c) and in wt, mdx, mdx:Smpd3^−/− (#238), and Smpd3^−/− (#29) mice at 16 weeks of age (d). The number of animals used is indicated in parentheses. *p < 0.05, **p < 0.01, ***p < 0.001