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Table 2 Study characteristics of IPD participant, sample site, and test type

From: At what times during infection is SARS-CoV-2 detectable and no longer detectable using RT-PCR-based tests? A systematic review of individual participant data

Ref Author year How were IPD participants selected? Percentage of male Age median (years) Age mean (years) Age range (years) Sample site PCR test type; name of equipment if reported Genomic targets; primers reported/referenced/ included
[9] Cai 2020 IPD of almost all patients in study NR NR NR NR Not reported qRT-PCR; not reported ORF1ab, N-gene; not reported
[16] Chang 2020 IPD of all patients in study 69 36 Not reported IQR 24–43 Throat qRT-PCR; not reported Not reported; not reported
[10] Chen 2020a Initial or follow-up positive sputum or faecal samples paired with a follow-up negative pharyngeal sample 64 37 37 IQR 30–49 Faeces, sputum, URT (pharyngeal) qRT-PCR; not reported ORF1ab, N-gene; not reported
[12] Chen 2020b IPD of all patients in study 51 51   IQR 36–64 URT qRT-PCR; not reported ORF1ab, N-gene; not reported
[29] He 2020 IPD for all 94 patients presented, but could only extract 19 IPD from overlapping graphs 50 47    Throat qRT-PCR; not reported N-gene; not reported
[24] Hu 2020a IPD of all patients in study 48 46 NR NR Nasopharyngeal qRT-PCR; not reported ORF1ab, N-gene; not reported
[30] Hu 2020b IPD of almost all patients in study 33 33 38 5–95 Throat qRT-PCR; BGI Genomics ORF1ab; primers included
[28] Jiehao 2020 IPD of all patients in study 40 7 6 3 months–11 years URT qRT-PCR; not reported ORF1ab, N-gene; not reported
[31] Kujawski 2020 IPD of all patients in study 67 53   21–68 Throat, nasopharyngeal, sputum, urine, faeces qRT-PCR; not reported N-gene; not reported
[39] Lavezzo 2020 All residents identified with infection 50 NR NR NR Nasopharyngeal qRT-PCR; One Step Real Time kit (Thermo Fisher Scientific, USA) E-gene, RdRp; primers referenced
[27] Lescure 2020 IPD of all patients in study 60 46 47 30–80 Nasopharyngeal, faeces, conjunctiva, urine, blood, LRT (pleural) qRT-PCR; not reported E-gene, RdRp; primers included
[34] Li 2020 IPD of all patients in study 57 42 43 21–62 Throat qRT-PCR; not reported Not reported; not reported
[14] Liu 2020a 25 participants with serial samples tested for PCR NR NA NA NA Nasopharyngeal qRT-PCR; not reported Not reported; not reported
[32] Liu 2020b IPD of all patients in study 40 42   34–50 Mixed URT (nasal, throat) qRT-PCR; not reported E-gene, RdRp, N-gene; not reported
[18] Lo 2020 IPD of all patients in study 30 54 NR NR Faeces, nasopharyngeal, urine qRT-PCR; BioGerm ORF1ab, N-gene; not reported
[20] Lu 2020 IPD of all patients in study NR NR NR NR Sputum, URT (pharyngeal), faeces, blood qRT-PCR; not reported ORF1ab, N-gene; primers included
[19] Song 2020 IPD of all patients in study 100 NR NR 22–67 URT (pharyngeal) qRT-PCR; Huirui biotechnology Not reported; not reported
[13] To 2020 IPD of all patients in study 58 63   37 to 75 Saliva qRT-PCR; QuantiNova SYBR Green RT-PCR kit (Qiagen) S-gene; not reported
[17] Wolfel 2020 IPD of all patients in study NR Not reported Not reported Not reported Sputum, faeces, URT (pharyngeal) qRT-PCR; Tib-Molbiol, Germany E-gene, RdRp; not reported
[37] Wu 2020 Retrospective 41 patients with positive faecal samples only 53 NR NR NR Throat, faeces qRT-PCR; 2019-nCOV Real Time RT-PCR kit (LifeRiver Ltd) E-gene, RdRp, N-gene
[40] Wyllie 2020 Patients with multiple nasopharyngeal swabs or multiple saliva swabs Inpatients (52), healthcare workers (16) NR 61 23–92 Nasopharyngeal, saliva qRT-PCR; US CDC RT-PCR primer/probe sets N-gene; primers referenced
[21] Xia 2020 IPD of all patients in study 70 51 55 13–83 Sputum, conjunctiva qRT-PCR; BioGerm Not reported; not reported
[23] Xiao 2020 IPD of all patients in study 61 55 55 25–83 URT (pharyngeal) qRT-PCR; Shanghai Huirui Biotechnology Co. ORF1ab, N-gene; not reported
[33] Xu 2020a IPD of almost all patients in study 49 3 groups: imported 35 [29–51], secondary 37 [24–47.5], tertiary 53 [35–65]   24–65 Throat qRT-PCR; BioGerm ORF1ab, N-gene; not reported
[36] Xu 2020b IPD of all patients in study 60 7 8 2 months–16 years Nasopharyngeal, faeces qRT-PCR; BioGerm ORF1ab, N-gene; primers included
[11] Yang 2020 Not reported how 13 patients for serial sampling IPD data chosen 51 52   2–86 Mixed URT (nasal swabs, throat swabs) and mixed LRT (sputum and bronchoalveolar lavage fluid (BALF)) qRT-PCR; GeneoDX Co. Not reported; not reported
[26] Young 2020 IPD of all patients in study 50 47   31–73 Nasopharyngeal, faeces, urine, blood qRT-PCR; not reported ORF1ab, N-gene, S-gene; primers included
[22] Yuan 2020 IPD of all patients in study 33 64 59 36–71 Nasopharyngeal, faeces qRT-PCR; not reported E-gene, RdRp, N-gene; not reported
[25] Zhang 2020a Not reported NR NR NR NR URT (oral), faeces qRT-PCR; HiScript®II One Step qRT-PCR SYBR®Green Kit (Vazyme Biotech Co.) S-gene; primer included
[35] Zhang 2020b IPD of all patients in study 86 26 22 10 months–35 years Throat, faeces, blood qRT-PCR; not reported Not reported; not reported
[38] Zheng 2020 IPD of all patients in study 60 55 NR NR Sputum, faeces, blood qRT-PCR; SARS-CoV-2 detection kit (BoJie Shanghai) ORF1ab; not reported
[15] Zou 2020 IPD of almost all patients in study 50 59   26–76 Throat, URT (nasal) qRT-PCR; not reported ORF1ab, N-gene; not reported