Study characteristic | Detail | Reference |
---|---|---|
Study design: representative recruitment | Representative participants • Community infection • Contact tracing including asymptomatic • Hospitalised patients | Population surveillance of Italian town, with PCR testing across [39] Retrospective cohort of 96 hospitalised patients [38] |
Study design: planned testing and follow-up | Informative sampling • Multiple sampling sites per participant • Planned schedule of sampling • Sampling continues after negative test results • Sampling continues after hospital discharge | Three samples per patient, multiple testing including prolonged testing even after multiple negative results [10] Population surveillance of Italian town over 18 days [39] Long follow-up post-hospital [16, 35, 36] Planned schedule of testing ([30], asymptomatic contact tracing follow-up [36,37,38]) |
Study design: sampling | Reporting of sampling methods (sample site, staff conducting test, sample volumes, and methods) | Most studies had very sparse reporting of sample collection methods. Example of fuller reporting [40] |
Individual participant data reporting for sharing | Examples of plots and tables that facilitated sharing of individual participant data | Retrospective cohort of 96 patients all tested with sputum, faeces, and blood. Plot shows time span of positive test results, hospitalisation timing, and disease severity for individual patients [38] Data showing time course of illness with PCR test results [9, 31] Data showing RT-PCR test results by patient and time point [10] Viral load over time [15] |