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Table 3 Association between different factors and 6-month mortality in the methylprednisolone group

From: The efficacy and safety of methylprednisolone in hepatitis B virus-related acute-on-chronic liver failure: a prospective multi-center clinical trial

Factors Univariate Multivariate
HR (95% CI) P HR (95% CI) P
Male 0.496 (0.169–1.451) 0.200   
Centersa 0.575   
Antiviral treatmenta 0.681   
Age (years) 1.006 (0.975–1.039) 0.695   
cirrhosis 1.254 (0.429–3.670) 0.679   
Time from onset to admission (days) 1.021 (1.001–1.043) 0.044 1.021 (0.997–1.045) 0.085
MELD scores 1.144 (1.053–1.244) 0.001   
lg HBV DNA 0.812 (0.653–1.008) 0.060   
HBV DNA positive 0.247 (0.105–0.584) 0.001 4.875 (1.596–14.889) 0.005
 HBeAg positive 1.130 (0.506–2.523) 0.765   
 HBsAg 1.000 (1.000–1.000) 0.184   
 ALT(U/L) 0.999 (0.999–1.000) 0.213   
 AST(U/L) 1.000 (0.999–1.001) 0.669   
 Bilirubin (μmol/L) 1.005 (1.002–1.008) 0.001 1.001 (0.998–1.004) 0.534
 Cholinesterase (IU/L) 1.000 (0.999–1.000) 0.375   
 AFP (ng/ml) 0.997 (0.994–1.001) 0.111   
 Albumin (g/L) 0.978 (0.872–1.096) 0.700   
 Blood urea nitrogen (mmol/L) 1.094 (0.941–1.271) 0.241   
 Creatinine (μmol/L) 1.000 (0.987–1.013) 0.976   
 NH3 (μmol/L) 1.005 (0.998–1.012) 0.152   
 Triglyceride (mmol/L) 0.731 (0.394–1.356) 0.320   
 Cholesterol (mmol/L) 0.896 (0.537–1.496) 0.675   
 White cell (× 109/L) 1.049 (0.942–1.168) 0.381   
 Red cell (× 109/L) 0.996 (0.611–1.622) 0.986   
 Hemoglobin (g/L) 0.998 (0.978–1.019) 0.870   
 Platelet (× 109/L) 0.999 (0.990–1.008) 0.851   
 Lymphocyte percentage 0.955 (0.904–1.008) 0.096   
 Monocyte percentage 1.181 (1.049–1.329) 0.006 1.156 (0.954–1.401) 0.138
Lymphocyte/monocyte ratio 0.533 (0.339–0.839) 0.007 0.537 (0.291–0.992) 0.047
 Procalcitonin (μg/L) 0.992 (0.732–1.344) 0.957   
 Neutrophil percentage 1.018 (0.978–1.060) 0.375   
 PTA (%) 0.929 (0.887–0.974) 0.002 0.901 (0.790–1.028) 0.122
 INR 2.764 (1.401–5.451) 0.003 0.613 (0.074–5.075) 0.650
 Ascites 2.467 (1.021–5.959) 0.045 1.143 (0.398–3.276) 0.804
 Infections 1.344 (0.588–3.072) 0.484   
 Electrolyte disturbance 0.045 (0.000–64.307) 0.403   
 HE 3.257 (1.347–7.873) 0.009 2.746 (0.868–8.683) 0.085
 Hypoalbuminemia 1.183 (0.404–3.464) 0.759   
 HRS 6.965 (0.899–53.954) 0.063   
  1. aRisk estimate statistics cannot be computed. They are only computed for two groups of data