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Table 3 Association between different factors and 6-month mortality in the methylprednisolone group

From: The efficacy and safety of methylprednisolone in hepatitis B virus-related acute-on-chronic liver failure: a prospective multi-center clinical trial

Factors

Univariate

Multivariate

HR (95% CI)

P

HR (95% CI)

P

Male

0.496 (0.169–1.451)

0.200

  

Centersa

–

0.575

  

Antiviral treatmenta

–

0.681

  

Age (years)

1.006 (0.975–1.039)

0.695

  

cirrhosis

1.254 (0.429–3.670)

0.679

  

Time from onset to admission (days)

1.021 (1.001–1.043)

0.044

1.021 (0.997–1.045)

0.085

MELD scores

1.144 (1.053–1.244)

0.001

  

lg HBV DNA

0.812 (0.653–1.008)

0.060

  

HBV DNA positive

0.247 (0.105–0.584)

0.001

4.875 (1.596–14.889)

0.005

 HBeAg positive

1.130 (0.506–2.523)

0.765

  

 HBsAg

1.000 (1.000–1.000)

0.184

  

 ALT(U/L)

0.999 (0.999–1.000)

0.213

  

 AST(U/L)

1.000 (0.999–1.001)

0.669

  

 Bilirubin (μmol/L)

1.005 (1.002–1.008)

0.001

1.001 (0.998–1.004)

0.534

 Cholinesterase (IU/L)

1.000 (0.999–1.000)

0.375

  

 AFP (ng/ml)

0.997 (0.994–1.001)

0.111

  

 Albumin (g/L)

0.978 (0.872–1.096)

0.700

  

 Blood urea nitrogen (mmol/L)

1.094 (0.941–1.271)

0.241

  

 Creatinine (μmol/L)

1.000 (0.987–1.013)

0.976

  

 NH3 (μmol/L)

1.005 (0.998–1.012)

0.152

  

 Triglyceride (mmol/L)

0.731 (0.394–1.356)

0.320

  

 Cholesterol (mmol/L)

0.896 (0.537–1.496)

0.675

  

 White cell (× 109/L)

1.049 (0.942–1.168)

0.381

  

 Red cell (× 109/L)

0.996 (0.611–1.622)

0.986

  

 Hemoglobin (g/L)

0.998 (0.978–1.019)

0.870

  

 Platelet (× 109/L)

0.999 (0.990–1.008)

0.851

  

 Lymphocyte percentage

0.955 (0.904–1.008)

0.096

  

 Monocyte percentage

1.181 (1.049–1.329)

0.006

1.156 (0.954–1.401)

0.138

Lymphocyte/monocyte ratio

0.533 (0.339–0.839)

0.007

0.537 (0.291–0.992)

0.047

 Procalcitonin (μg/L)

0.992 (0.732–1.344)

0.957

  

 Neutrophil percentage

1.018 (0.978–1.060)

0.375

  

 PTA (%)

0.929 (0.887–0.974)

0.002

0.901 (0.790–1.028)

0.122

 INR

2.764 (1.401–5.451)

0.003

0.613 (0.074–5.075)

0.650

 Ascites

2.467 (1.021–5.959)

0.045

1.143 (0.398–3.276)

0.804

 Infections

1.344 (0.588–3.072)

0.484

  

 Electrolyte disturbance

0.045 (0.000–64.307)

0.403

  

 HE

3.257 (1.347–7.873)

0.009

2.746 (0.868–8.683)

0.085

 Hypoalbuminemia

1.183 (0.404–3.464)

0.759

  

 HRS

6.965 (0.899–53.954)

0.063

  
  1. aRisk estimate statistics cannot be computed. They are only computed for two groups of data