Skip to main content

Table 2 Major observational studies of acute influenza and COVID-19 reporting ICU admission

From: Cardiovascular implications of COVID-19 versus influenza infection: a review

Study Country Design (N) Pre-existing CVD for patients in ICU, (%) ICU, N (%) ICU stay, days Requiring invasive mechanical ventilation, N (%)
Acute influenza
 Chacko et al. [17] India Retrospective 37 5.4 37 (100) 12 (9–15) 25 (67.6)
 Fagnoul et al. [18] Belgium Retrospective 46 10.9 46 (100) 9 (2–16) 26 (56.5)
 Han et al. [19] China Retrospective 40 15.0 40 (100) NR NR
 Ludwig et al. [20] USA Retrospective 600 28.8 44/143 (30.8) 6 (2–30) NR
 Chao et al. [45] Taiwan Retrospective 125 35.2 125 (100) 12.7 (10.2)* NR
 Gao et al. [26] China Retrospective 321 NR 260 (81.o) 10 (3–20) 196 (61.1)
Summary estimate, % (95% CI) NA NA 1169 20.6 (13.2, 30.7) 93.8 (74.7, 98.7)§ NA 61.1 (56.3, 65.7)
COVID-19
 Cummings et al. [27] USA Prospective Cohort 257 NR 203 (79.0) NR 203 (80.0)
 Richardson et al. [29] USA Retrospective case-series 5700 NR 1281 (22.5) NR 1151 (20.2)
 Goyal, 2020 [30] USA Retrospective case-series 393 NR NR NR 130 (33.1)
 Arentz et al. [31] USA Retrospective case-series 21 NR 21 (100) NR NR
 Chen et al. [28] China Retrospective 99 NR NR NR 4 (4.0)
 Zhou et al. [32] China Retrospective Cohort 191 NR 50 (26.2) 8 (4–12) 32 (16.8)
 Huang et al. [4] China Cohort 41 NR 13 (31.7) NR 2 (4.9)
 Guan et al. [33] China Cohort 1099 NR 55 (5.0) NR 25 (2.3)
 Wang et al. [35] China Retrospective case-series 138 8.0 36 (26.1) NR 6 (4.3)
 Yang et al. [36] China Retrospective 52 9.6 52 (100) NR 22 (42.3)
 Wu et al. [37] China Cohort 201 NR 53 (26.4) NR 5 (2.5)
 Shi et al. [39] China Cohort 416 NR NR NR 32 (7.7)
 Yu et al. [40] China Prospective 226 11.5 226 (100) NR 85 (37.6)
Summary estimate, % (95% CI) NA NA 8834 10.2 (7.6, 13.5) 47.2 (28.9, 66.3) NA 14.4 (8.0, 24.5)
  1. ICU stay reported as median (IQR)
  2. ICU intensive care unit, CVD cardiovascular disease, NR not reported, NA not applicable
  3. *Data reported as mean (SD)
  4. Summary estimates were calculated using meta-analysis of proportions. Logit transformed proportions and corresponding 95% confidence intervals (CIs) from studies reporting the aforementioned data were pooled using random-effects model and presented as % (95% CI)
  5. §Results including studies presenting 100% ICU admissions. Pooled proportional analysis of Gao 2020 and Ludwig 2017 yielded 58.0% (13.1%, 92.7%)