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Table 3 Characteristics of colon and rectal cancer prediction models developed in the derivation cohort, overall and by sex

From: Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score

Predictor variables

Hazard ratios (95% confidence intervals), p-value

Colon cancer

Rectal cancer

Both sexes

Men

Women

Both sexes

Men

Women

Age at recruitment, per 10 years

2.30 (2.17 to 2.44)

< .001

2.11 (1.93 to 2.30)

< .001

2.31 (2.15 to 2.49)

< .001

2.02 (1.87 to 2.18)

< .001

2.10 (1.88 to 2.35)

< .001

1.86 (1.68 to 2.04)

< .001

Waist circumference, per 10 cm

1.14 (1.10 to 1.18)

< .001

1.27 (1.19 to 1.35)

< .001

1.07 (1.02 to 1.12)

0.006

1.10 (1.05 to 1.15)

< .001

    

Height, per 10 cm

1.14 (1.08 to 1.19)

< .001

  

1.17 (1.08 to 1.28)

< .001

1.15 (1.08 to 1.23)

< .001

    

Daily alcohol consumption, high

1.12 (1.02 to 1.22)

0.017

    

1.21 (1.07 to 1.37)

0.002

1.27 (1.08 to 1.50)

0.004

  

Ever smoker, yes

1.18 (1.08 to 1.28)

< .001

1.18 (1.02 to 1.35)

0.024

1.14 (1.02 to 1.28)

0.018

1.32 (1.17 to 1.49)

< .001

1.44 (1.19 to 1.74)

< .001

  

Physically active, yes

0.88 (0.80 to 0.98)

0.025

  

0.84 (0.72 to 0.99)

0.035

      

Vegetables, per 100 g/day

0.91 (0.89 to 0.94)

< .001

0.90 (0.85 to 0.94)

< .001

0.93 (0.89 to 0.97)

0.001

0.92 (0.88 to 0.96)

< .001

0.88 (0.82 to 0.93)

< .001

  

Fruits, per 100 g/day

            

Dark bread, per 50 g/day

0.96 (0.93 to 0.99)

0.017

0.94 (0.90 to 0.98)

0.008

        

Dairy products, per 100 g/day

0.98 (0.96 to 0.99)

0.007

0.96 (0.93 to 0.98)

0.001

        

Red meat, per 50 g/day

            

Poultry per, 50 g/day

            

Processed meat, per 50 g/day

      

1.20 (1.10 to 1.31)

< .001

  

1.27 (1.09 to 1.47)

0.002

Fish, per 50 g/day

            

Sugar and confectionary, per 50 g/day

            

Soft drinks, per 100 g/day

      

1.03 (1.00 to 1.06)

0.025

  

1.06 (1.02 to 1.10)

0.006

Survival functionm (10 years)*

0.9966

0.9953

0.9970

0.9979

0.9968

0.9982

Risk Scorem†

7.156

5.802

7.137

6.8764

3.9117

3.2985

Absolute Riskm (10 years)‡

0.48%

0.62%

0.41%

0.28%

0.42%

0.21%

  1. *Survival functionm (10 years): 10-year survival function of average predictor values of the derivation cohort
  2. †Risk Scorem: Mean risk score calculated based on the sum of beta coefficient products of average predictor values of the derivation cohort
  3. ‡Absolute Riskm: 10-year mean absolute risk of the derivation cohort
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BMC Medicine

ISSN: 1741-7015

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