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Table 3 Characteristics of colon and rectal cancer prediction models developed in the derivation cohort, overall and by sex

From: Development and validation of a lifestyle-based model for colorectal cancer risk prediction: the LiFeCRC score

Predictor variables Hazard ratios (95% confidence intervals), p-value
Colon cancer Rectal cancer
Both sexes Men Women Both sexes Men Women
Age at recruitment, per 10 years 2.30 (2.17 to 2.44) < .001 2.11 (1.93 to 2.30) < .001 2.31 (2.15 to 2.49) < .001 2.02 (1.87 to 2.18) < .001 2.10 (1.88 to 2.35) < .001 1.86 (1.68 to 2.04) < .001
Waist circumference, per 10 cm 1.14 (1.10 to 1.18) < .001 1.27 (1.19 to 1.35) < .001 1.07 (1.02 to 1.12) 0.006 1.10 (1.05 to 1.15) < .001     
Height, per 10 cm 1.14 (1.08 to 1.19) < .001    1.17 (1.08 to 1.28) < .001 1.15 (1.08 to 1.23) < .001     
Daily alcohol consumption, high 1.12 (1.02 to 1.22) 0.017      1.21 (1.07 to 1.37) 0.002 1.27 (1.08 to 1.50) 0.004   
Ever smoker, yes 1.18 (1.08 to 1.28) < .001 1.18 (1.02 to 1.35) 0.024 1.14 (1.02 to 1.28) 0.018 1.32 (1.17 to 1.49) < .001 1.44 (1.19 to 1.74) < .001   
Physically active, yes 0.88 (0.80 to 0.98) 0.025    0.84 (0.72 to 0.99) 0.035       
Vegetables, per 100 g/day 0.91 (0.89 to 0.94) < .001 0.90 (0.85 to 0.94) < .001 0.93 (0.89 to 0.97) 0.001 0.92 (0.88 to 0.96) < .001 0.88 (0.82 to 0.93) < .001   
Fruits, per 100 g/day             
Dark bread, per 50 g/day 0.96 (0.93 to 0.99) 0.017 0.94 (0.90 to 0.98) 0.008         
Dairy products, per 100 g/day 0.98 (0.96 to 0.99) 0.007 0.96 (0.93 to 0.98) 0.001         
Red meat, per 50 g/day             
Poultry per, 50 g/day             
Processed meat, per 50 g/day        1.20 (1.10 to 1.31) < .001    1.27 (1.09 to 1.47) 0.002
Fish, per 50 g/day             
Sugar and confectionary, per 50 g/day             
Soft drinks, per 100 g/day        1.03 (1.00 to 1.06) 0.025    1.06 (1.02 to 1.10) 0.006
Survival functionm (10 years)* 0.9966 0.9953 0.9970 0.9979 0.9968 0.9982
Risk Scorem 7.156 5.802 7.137 6.8764 3.9117 3.2985
Absolute Riskm (10 years)‡ 0.48% 0.62% 0.41% 0.28% 0.42% 0.21%
  1. *Survival functionm (10 years): 10-year survival function of average predictor values of the derivation cohort
  2. †Risk Scorem: Mean risk score calculated based on the sum of beta coefficient products of average predictor values of the derivation cohort
  3. ‡Absolute Riskm: 10-year mean absolute risk of the derivation cohort