Table 4 HLA-DQ genotype and serum IL-2 after gluten
From: Patient factors influencing acute gluten reactions and cytokine release in treated coeliac disease
Genotype group†, participants (n) | Serum IL-2 concentrations, median (interquartile range) pg/ml | Responders‡ participants, n (%) | |||
|---|---|---|---|---|---|
2 h | 4 h | 6 h | Maximum†† | ||
1. DQ2.5 positive (266) | 2.2 (< 0.5–8.6) | 3.2 (0.6–10.7) | 1.2 (< 0.5–4.5) | 4.6 (0.8–13.1) | 217 (82%) |
2. DQ2.5 negative‡‡ (29) | < 0.5 (< 0.5–1.2) | 0.6 (< 0.5–2.9) | < 0.5 (< 0.5–1.1) | 0.6 (< 0.5–3.6) | 17 (52%) |
3. DQ2.5, 2.5 (34) | 2.7 (0.8–8.0) | 3.7 (1.3–9.4) | 1.6 (0.6–4.9) | 5.9 (1.8–10.8) | 29 (85%) |
4. DQ2.5, 2.2 (56) | 5.5 (2.5–12.9) | 9.0 (2.6–22.9) | 3.7 (0.9–7.0) | 10.2 (4.7–24.5) | 52 (93%) |
5. DQ2.5, 7 (15) | 0.8 (< 0.5–7.4) | 1.8 (< 0.5–5.0) | 0.8 (< 0.5–1.4) | 1.8 (< 0.5–9.0) | 11 (73%) |
6. DQ2.5, 8 (36) | 1.1 (< 0.5–6.7) | 2.4 (< 0.5–5.7) | 0.9 (< 0.5–2.8) | 2.7 (0.6–8.5) | 28 (78%) |
7. DQ2.5trans (18) | 1.5 (0.7–8.2) | 3.3 (0.9–12.5) | 1.5 (0.6–6.9) | 3.3 (0.9–12.5) | 16 (89%) |
8. DQ2.5cis, X (107) | 1.4 (< 0.5–6.3) | 1.9 (< 0.5–8.1) | 0.8 (< 0.5–3.0) | 2.5 (0.6–10.4) | 81 (76%) |