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Table 1 Association of genetically predicted cortisol (P value< 5 × 10−6 and r2 < 0.001) based on 3 separate data sources (CORtisol NETwork (CORNET) consortium, Shin GWAS, and Long GWAS) with ischemic heart disease (IHD) based on the CARDIoGRAMplusC4D 1000 Genomes-based GWAS (1000 Genomes) with replication based on the UK Biobank using Mendelian randomization (MR) with different methods

From: The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study

Exposure sources Outcome sources SNPs F-statistic Method Odds ratio 95% CI   P value IVW MR-Egger
Cochran’s Q-statistic P value Intercept P value I2
CORNET 2014 1000 Genomes 6 28.3 IVW 0.98 0.93 1.03 0.42 2.18 0.82   
    WM 1.00 0.93 1.07 0.95     
    MR-Egger 0.98 0.90 1.06 0.63    0.96 81.5%
    MR-PRESSO 0.98 0.93 1.02 0.28     
UK Biobank 6 28.3 IVW 0.99 0.93 1.05 0.71 2.29 0.81   
    WM 0.99 0.92 1.07 0.82     
    MR-Egger 0.99 0.89 1.10 0.85    0.96 71.3%
    MR-PRESSO 0.99 0.94 1.04 0.61     
Shin GWAS 2014 1000 Genomes 5 23.9 IVW 0.74 0.47 1.17 0.19 4.52 0.34   
    WM 0.78 0.45 1.35 0.37     
    MR-Egger 0.84 0.32 2.20 0.72    0.77 35.3%
    MR-PRESSO 0.74 0.39 1.41 0.26     
UK Biobank 5 23.9 IVW 0.96 0.56 1.67 0.89 6.21 0.18   
    WM 1.09 0.61 1.95 0.76     
    MR-Egger 1.58 0.58 4.28 0.37    0.25 9.3%
    MR-PRESSO 0.96 0.44 2.10 0.90     
Long GWAS 2017 1000 Genomes 18 14.9 IVW 1.02 0.99 1.05 0.18 21.43 0.21   
    WM 1.01 0.98 1.05 0.44     
    MR-Egger 1.02 0.96 1.09 0.47    0.91 0%
    MR-PRESSO 1.02 0.99 1.05 0.20     
UK Biobank 18 14.9 IVW 0.99 0.96 1.01 0.31 15.35 0.57   
    WM 0.99 0.95 1.03 0.57     
    MR-Egger 1.00 0.94 1.05 0.89    0.70 0%
    MR-PRESSO 0.99 0.96 1.01 0.30     
  1. Abbreviations: CI confidence interval, IVW inverse variance weighting, MR Mendelian randomization, SNP single nucleotide polymorphism, WM weighted median