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Table 2 Association of genetically predicted cortisol (P value< 5 × 10−6 and r2 < 0.001) based on 3 separate data sources (CORtisol NETwork (CORNET) consortium, Shin GWAS, and Long GWAS) with ischemic stroke based on the MEGASTROKE using Mendelian randomization (MR) with different methods

From: The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study

Exposure sources Outcome sources SNPs F-statistic Method Odds ratio 95% CI   P value IVW MR-Egger
Cochran’s Q-statistic P value Intercept P value I2
CORNET 2014 MEGASTROKE 6 28.3 IVW 0.99 0.91 1.08 0.83 8.00 0.16   
    WM 0.99 0.91 1.08 0.83     
    MR-Egger 0.95 0.82 1.10 0.46    0.44 73.5%
    MR-PRESSO 0.99 0.88 1.11 0.84     
Shin GWAS 2014 MEGASTROKE 5 23.9 IVW 0.39 0.24 0.64 0.0002 3.15 0.53   
    WM 0.48 0.25 0.93 0.03     
    MR-Egger 0.62 0.25 1.55 0.31    0.25 14.5%
    MR-PRESSO 0.39 0.21 0.73 0.01     
Long GWAS 2017 MEGASTROKE 18 14.9 IVW 1.00 0.97 1.03 0.90 8.93 0.94   
    WM 1.00 0.96 1.04 0.88     
    MR-Egger 1.02 0.96 1.09 0.47    0.45 0%
    MR-PRESSO 1.00 0.98 1.02 0.86     
  1. Abbreviations: CI confidence interval, IVW inverse variance weighting, MR Mendelian randomization, SNP single nucleotide polymorphism, WM weighted median