The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study

Table 2 Association of genetically predicted cortisol (P value< 5 × 10⁻⁶ and r² < 0.001) based on 3 separate data sources (CORtisol NETwork (CORNET) consortium, Shin GWAS, and Long GWAS) with ischemic stroke based on the MEGASTROKE using Mendelian randomization (MR) with different methods

Exposure sources	Outcome sources	SNPs	F-statistic	Method	Odds ratio	95% CI		P value	IVW		MR-Egger
Exposure sources	Outcome sources	SNPs	F-statistic	Method	Odds ratio	95% CI		P value	Cochran’s Q-statistic	P value	Intercept P value	I²
CORNET 2014	MEGASTROKE	6	28.3	IVW	0.99	0.91	1.08	0.83	8.00	0.16
				WM	0.99	0.91	1.08	0.83
				MR-Egger	0.95	0.82	1.10	0.46			0.44	73.5%
				MR-PRESSO	0.99	0.88	1.11	0.84
Shin GWAS 2014	MEGASTROKE	5	23.9	IVW	0.39	0.24	0.64	0.0002	3.15	0.53
				WM	0.48	0.25	0.93	0.03
				MR-Egger	0.62	0.25	1.55	0.31			0.25	14.5%
				MR-PRESSO	0.39	0.21	0.73	0.01
Long GWAS 2017	MEGASTROKE	18	14.9	IVW	1.00	0.97	1.03	0.90	8.93	0.94
				WM	1.00	0.96	1.04	0.88
				MR-Egger	1.02	0.96	1.09	0.47			0.45	0%
				MR-PRESSO	1.00	0.98	1.02	0.86

Abbreviations: CI confidence interval, IVW inverse variance weighting, MR Mendelian randomization, SNP single nucleotide polymorphism, WM weighted median

ISSN: 1741-7015