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Table 3 Association of genetically predicted cortisol (P value< 5 × 10−6 and r2 < 0.001) based on 3 separate data sources (CORtisol NETwork (CORNET) consortium, Shin GWAS, and Long GWAS) with type 2 diabetes (T2DM) based on the DIAbetes Meta-ANalysis of Trans-Ethnic association studies (DIAMANTE) with checking based on the UK Biobank using Mendelian randomization (MR) with different methods

From: The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study

Exposure sources Outcome sources SNPs F-statistic Method Odds ratio 95% CI   P value IVW MR-Egger
Cochran’s Q-statistic P value Intercept P value I2
CORNET 2014 DIAMANTE 6 28.3 IVW 1.00 0.96 1.04 0.92 4.23 0.52   
    WM 0.99 0.94 1.05 0.80     
    MR-Egger 0.99 0.92 1.06 0.72    0.70 72.9%
    MR-PRESSO 1.00 0.95 1.05 0.92     
UK Biobank 6 28.3 IVW 1.00 0.91 1.10 0.999 7.48 0.19   
    WM 1.02 0.92 1.13 0.69     
    MR-Egger 1.11 0.98 1.26 0.10    0.04 71.4%
    MR-PRESSO 1.00 0.88 1.13 0.999     
Shin GWAS 2014 DIAMANTE 5 23.9 IVW 0.68 0.46 1.02 0.07 6.93 0.14   
    WM 0.70 0.46 1.06 0.09     
    MR-Egger 0.70 0.29 1.69 0.43    0.96 3.2%
    MR-PRESSO 0.68 0.39 1.21 0.14     
UK Biobank 5 23.9 IVW 0.68 0.34 1.39 0.29 6.70 0.15   
    WM 0.71 0.34 1.48 0.36     
    MR-Egger 1.13 0.28 4.52 0.86    0.40 10.6%
    MR-PRESSO 0.68 0.25 1.86 0.35     
Long GWAS 2017 DIAMANTE 18 14.9 IVW 1.00 0.97 1.03 0.95 57.78 < 0.0001   
    WM 0.99 0.96 1.02 0.33     
    MR-Egger 0.99 0.92 1.05 0.69    0.67 0%
    MR-PRESSOa 0.99 0.96 1.01 0.33     
UK Biobank 18 14.9 IVW 1.01 0.97 1.05 0.60 24.35 0.11   
    WM 1.01 0.96 1.05 0.74     
    MR-Egger 0.97 0.90 1.05 0.43    0.24 0%
    MR-PRESSO 1.01 0.97 1.05 0.61     
  1. Abbreviations: CI confidence interval, IVW inverse variance weighting, MR Mendelian randomization, SNP single nucleotide polymorphism, WM weighted median
  2. aMR-PRESSO estimate was obtained by excluding 1 outlier (rs117226077)