Table 3 Association of genetically predicted cortisol (P value< 5 × 10⁻⁶ and r² < 0.001) based on 3 separate data sources (CORtisol NETwork (CORNET) consortium, Shin GWAS, and Long GWAS) with type 2 diabetes (T2DM) based on the DIAbetes Meta-ANalysis of Trans-Ethnic association studies (DIAMANTE) with checking based on the UK Biobank using Mendelian randomization (MR) with different methods

CORNET 2014

DIAMANTE

6

28.3

IVW

1.00

0.96

1.04

0.92

4.23

0.52

WM

0.99

0.94

1.05

0.80

MR-Egger

0.99

0.92

1.06

0.72

0.70

72.9%

MR-PRESSO

1.00

0.95

1.05

0.92

UK Biobank

6

28.3

IVW

1.00

0.91

1.10

0.999

7.48

0.19

WM

1.02

0.92

1.13

0.69

MR-Egger

1.11

0.98

1.26

0.10

0.04

71.4%

MR-PRESSO

1.00

0.88

1.13

0.999

Shin GWAS 2014

DIAMANTE

5

23.9

IVW

0.68

0.46

1.02

0.07

6.93

0.14

WM

0.70

0.46

1.06

0.09

MR-Egger

0.70

0.29

1.69

0.43

0.96

3.2%

MR-PRESSO

0.68

0.39

1.21

0.14

UK Biobank

5

23.9

IVW

0.68

0.34

1.39

0.29

6.70

0.15

WM

0.71

0.34

1.48

0.36

MR-Egger

1.13

0.28

4.52

0.86

0.40

10.6%

MR-PRESSO

0.68

0.25

1.86

0.35

Long GWAS 2017

DIAMANTE

18

14.9

IVW

1.00

0.97

1.03

0.95

57.78

< 0.0001

WM

0.99

0.96

1.02

0.33

MR-Egger

0.99

0.92

1.05

0.69

0.67

0%

MR-PRESSO^a

0.99

0.96

1.01

0.33

UK Biobank

18

14.9

IVW

1.01

0.97

1.05

0.60

24.35

0.11

WM

1.01

0.96

1.05

0.74

MR-Egger

0.97

0.90

1.05

0.43

0.24

0%

MR-PRESSO

1.01

0.97

1.05

0.61