Skip to main content

Table 4 Association of genetically predicted cortisol (P value< 5 × 10−6 and r2 < 0.001) based on the CORtisol NETwork (CORNET) consortium, with cardiovascular disease (CVD) risk factors (adiposity based on the Genetic Investigation of Anthropometric Traits (GIANT), glycemic traits based on the Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), blood pressure based on the UK Biobank, and lipids based on the Global Lipids Genetics Consortium (GLGC)) using Mendelian randomization (MR) with different methods

From: The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study

Outcomes Sources SNPs F-statistic Method Mean difference 95% CI   P value IVW MR-Egger
Cochran’s Q-statistic P value Intercept P value I2
Adiposity
BMI GIANT 6 28.3 IVW − 0.001 − 0.01 0.01 0.85 2.37 0.80   
    WM − 0.003 − 0.02 0.01 0.72     
    MR-Egger 0.01 − 0.01 0.03 0.55    0.36 71.3%
    MR-PRESSO − 0.001 − 0.01 0.01 0.80     
WHR GIANT 6 28.3 IVW − 0.01 − 0.02 0.01 0.26 7.55 0.18   
    WM − 0.01 − 0.02 0.01 0.53     
    MR-Egger 0.003 − 0.02 0.03 0.76    0.17 71.8%
    MR-PRESSO − 0.01 − 0.03 0.01 0.31     
Glycemic traits
HbA1c MAGIC 6 28.3 IVW − 0.01 − 0.03 0.01 0.46 5.89 0.32   
    WM − 0.005 − 0.03 0.02 0.72     
    MR-Egger 0.004 − 0.03 0.04 0.80    0.39 27.6%
    MR-PRESSO − 0.01 − 0.03 0.02 0.49     
Glucose MAGIC 6 28.3 IVW 0.02 − 0.004 0.05 0.10 4.64 0.46   
    WM 0.02 − 0.02 0.05 0.31     
    MR-Egger 0.04 − 0.004 0.08 0.08    0.33 73.1%
    MR-PRESSO 0.02 − 0.01 0.05 0.15     
Insulin MAGIC 6 28.3 IVW 0.01 − 0.02 0.04 0.45 3.12 0.68   
    WM 0.01 − 0.02 0.05 0.51     
    MR-Egger 0.01 − 0.04 0.05 0.77    0.82 73.1%
    MR-PRESSO 0.01 − 0.02 0.04 0.38     
Blood pressure
 Systolic BP UK Biobank 6 28.3 IVW 0.01 − 0.03 0.04 0.71 21.11 0.001   
    WM − 0.002 − 0.02 0.02 0.86     
    MR-Egger − 0.03 − 0.06 − 0.003 0.03    0.001 71.5%
    MR-PRESSOa − 0.001 − 0.02 0.02 0.93     
 Diastolic BP UK Biobank 6 28.3 IVW 0.001 − 0.03 0.03 0.93 12.87 0.02   
    WM 0.01 − 0.01 0.03 0.52     
    MR-Egger − 0.02 − 0.06 0.01 0.18    0.07 71.5%
    MR-PRESSO 0.001 − 0.03 0.04 0.93     
Lipids
 Total Cholesterol GLGC 6 28.3 IVW − 0.02 − 0.06 0.01 0.21 5.39 0.37   
    WM − 0.04 − 0.08 0.01 0.12     
    MR-Egger − 0.04 − 0.11 0.02 0.20    0.48 74.7%
    MR-PRESSO − 0.02 − 0.07 0.03 0.26     
 HDL-Cholesterol GLGC 6 28.3 IVW 0.01 − 0.04 0.05 0.80 9.36 0.10   
    WM − 0.003 − 0.05 0.04 0.89     
    MR-Egger − 0.04 − 0.10 0.03 0.28    0.11 75.1%
    MR-PRESSO 0.01 − 0.06 0.07 0.81     
 LDL-Cholesterol GLGC 6 28.3 IVW − 0.03 − 0.07 0.003 0.07 4.20 0.52   
    WM − 0.04 − 0.09 0.005 0.08     
    MR-Egger − 0.04 − 0.10 0.02 0.19    0.78 75.4%
    MR-PRESSO − 0.03 − 0.08 0.01 0.11     
 Triglycerides GLGC 6 28.3 IVW − 0.01 − 0.04 0.03 0.70 2.16 0.83   
    WM − 0.01 − 0.05 0.03 0.69     
    MR-Egger − 0.01 − 0.06 0.04 0.72    0.88 75.8%
    MR-PRESSO − 0.01 − 0.04 0.02 0.59     
  1. Abbreviations: BP blood pressure, CI confidence interval, HDL high-density lipoprotein, LDL low-density lipoprotein, IVW inverse variance weighting, MR Mendelian randomization, SNP single nucleotide polymorphism, WM weighted median
  2. aMR-PRESSO estimate was obtained by excluding 1 outlier (rs6830)