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Table 6 Association of genetically predicted ischemic heart disease (IHD) and genetically predicted type 2 diabetes (T2DM) (P value< 5 × 10−8 and r2 < 0.001) based on the UK Biobank with cortisol based on the Crawford et al. study [19] using Mendelian randomization (MR) with different methods

From: The role of cortisol in ischemic heart disease, ischemic stroke, type 2 diabetes, and cardiovascular disease risk factors: a bi-directional Mendelian randomization study

Exposure sources Outcome sources SNPs F-statistic Method Beta 95% CI   P value IVW MR-Egger
Cochran’s Q-statistic P value Intercept P value I2
IHD Cortisol 32 60.2 IVW − 0.001 − 0.07 0.07 0.97 30.18 0.51   
(UK Biobank) (Crawford 2019)    WM 0.001 − 0.10 0.11 0.99     
    MR-Egger − 0.03 − 0.22 0.16 0.78    0.78 94.9%
    MR-PRESSO − 0.001 − 0.07 0.07 0.97     
T2DM Cortisol 35 73.4 IVW − 0.004 − 0.06 0.05 0.88 46.44 0.08   
(UK Biobank) (Crawford 2019)    WM 0.002 − 0.07 0.08 0.97     
    MR-Egger 0.02 − 0.12 0.15 0.81    0.74 96.6%
    MR-PRESSO − 0.004 − 0.06 0.05 0.88     
  1. Abbreviations: CI confidence interval, IVW inverse variance weighting, MR Mendelian randomization, SNP single nucleotide polymorphism, WM weighted median