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Table 4 Diagnostic performance of PSA, risk factors, the 25-Gene Panel urine test, and their combinations for PCa diagnosis in the PSA Cohort and FH Cohort

From: Development and validation of a 25-Gene Panel urine test for prostate cancer diagnosis and potential treatment follow-up

PSA, age, and 25-Gene Panel in the PSA Cohort (n = 414)

 

Univariate

Multivariate (age, PSA, 25-Gene)

Multivariate (PSA, 25-Gene)

Multivariate (age, 25-Gene)

 

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

Age

0.46

0.5 (2.4–0.1)

0.516 (0.572–0.460)

0.20

1.0 (1.1–1.0)

–

–

–

–

0.08

1.0 (1.0–1.1)

–

PSA

< 0.0001

6.9 (12.2–3.9)

0.710 (0.759–0.661)

< 0.0001

1.1 (1.1–1.0)

–

< 0.0001

1.1 (1.0–1.1)

–

–

–

–

25-Gene

< 0.0001

107.3 (213.2–54.0)

0.939 (0.962–0.916)

< 0.0001

281.8 (741.9–107.0)

–

< 0.0001

255.0 (644.1–101.0)

–

< 0.0001

116.2 (237.1–57.0)

–

Combo

–

–

–

< 0.0001

194.5 (429.1–88.1)

0.967 (0.984–0.950)

< 0.0001

195.5 (431.4–88.6)

0.961 (0.980–0.942)

< 0.0001

106.6 (212.0–53.7)

0.923 (0.949–0.897)

PSA at 4 ng/mL cutoff, age, and 25-Gene Panel in the PSA Cohort (n = 414)

 

Univariate

Multivariate (age, PSA-4, 25-Gene)

Multivariate (PSA-4, 25-Gene)

 
 

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

   

Age

0.46

0.5 (2.4–0.1)

0.516 (0.572–0.460)

0.08

1.0 (1.1–1.0)

–

–

–

–

   

PSA-4

0.001

2.3 (3.7–1.4)

0.588 (0.642–0.534)

0.20

1.7 (3.8–0.8)

–

0.21

1.7 (3.8–0.7)

–

   

25-Gene

< 0.0001

107.3 (213.2–54.0)

0.939 (0.962–0.916)

< 0.0001

112.6 (230.0–55.1)

–

< 0.0001

103.9 (206.7–52.2)

–

   

Combo

–

–

–

< 0.0001

106.6 (212.0–53.7)

0.927 (0.953–0.901)

< 0.0001

107.3 (213.2–54.0)

0.942 (0.965–0.919)

   

PCa family history, age, and 25-Gene Panel in the FH Cohort (n = 451)

 

Univariate

Multivariate (age, PCa FH, 25-Gene)

Multivariate (PCa FH, 25-Gene)

Multivariate (age, 25-Gene)

 

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

p value

OR (95% CI)

AUC (95% CI)

Age

0.02

0.9 (1.0–0.9)

0.606 (0.706–0.506)

0.12

0.9 (1.0–0.7)

–

–

–

–

0.13

0.9 (1.0–0.8)

–

PCa FH

0.28

2.0 (6.6–0.6)

0.363 (0.448–0.278)

0.23

5.0 (67.1–0.4)

–

0.27

3.9 (45.6–0.3)

–

–

–

–

25-Gene

< 0.0001

3690.0 (33,894.8–401.7)

0.985 (1.013–0.957)

< 0.0001

5760.4 (74,490.3–445.5)

–

< 0.0001

4080.0 (39,436.1–422.1)

–

< 0.0001

4530.3 (48,645.8–421.9)

–

Combo

–

–

–

< 0.0001

3690.0 (33,894.8–401.7)

0.987 (1.013–0.961)

< 0.0001

3690.0 (33,894.8–401.7)

0.987 (1.013–0.961)

< 0.0001

3690.0 (33,894.8–401.7)

0.986 (1.013–0.959)

  1. 25-Gene 25-Gene Panel, OR odds ratio, AUC area under the ROC curve, CI confidence interval, PSA-4 PSA at 4 ng/mL cutoff, FH family history, Combo combination
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BMC Medicine

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