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Table 4 Diagnostic performance of PSA, risk factors, the 25-Gene Panel urine test, and their combinations for PCa diagnosis in the PSA Cohort and FH Cohort

From: Development and validation of a 25-Gene Panel urine test for prostate cancer diagnosis and potential treatment follow-up

PSA, age, and 25-Gene Panel in the PSA Cohort (n = 414)
  Univariate Multivariate (age, PSA, 25-Gene) Multivariate (PSA, 25-Gene) Multivariate (age, 25-Gene)
  p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI)
Age 0.46 0.5 (2.4–0.1) 0.516 (0.572–0.460) 0.20 1.0 (1.1–1.0) 0.08 1.0 (1.0–1.1)
PSA < 0.0001 6.9 (12.2–3.9) 0.710 (0.759–0.661) < 0.0001 1.1 (1.1–1.0) < 0.0001 1.1 (1.0–1.1)
25-Gene < 0.0001 107.3 (213.2–54.0) 0.939 (0.962–0.916) < 0.0001 281.8 (741.9–107.0) < 0.0001 255.0 (644.1–101.0) < 0.0001 116.2 (237.1–57.0)
Combo < 0.0001 194.5 (429.1–88.1) 0.967 (0.984–0.950) < 0.0001 195.5 (431.4–88.6) 0.961 (0.980–0.942) < 0.0001 106.6 (212.0–53.7) 0.923 (0.949–0.897)
PSA at 4 ng/mL cutoff, age, and 25-Gene Panel in the PSA Cohort (n = 414)
  Univariate Multivariate (age, PSA-4, 25-Gene) Multivariate (PSA-4, 25-Gene)  
  p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI)    
Age 0.46 0.5 (2.4–0.1) 0.516 (0.572–0.460) 0.08 1.0 (1.1–1.0)    
PSA-4 0.001 2.3 (3.7–1.4) 0.588 (0.642–0.534) 0.20 1.7 (3.8–0.8) 0.21 1.7 (3.8–0.7)    
25-Gene < 0.0001 107.3 (213.2–54.0) 0.939 (0.962–0.916) < 0.0001 112.6 (230.0–55.1) < 0.0001 103.9 (206.7–52.2)    
Combo < 0.0001 106.6 (212.0–53.7) 0.927 (0.953–0.901) < 0.0001 107.3 (213.2–54.0) 0.942 (0.965–0.919)    
PCa family history, age, and 25-Gene Panel in the FH Cohort (n = 451)
  Univariate Multivariate (age, PCa FH, 25-Gene) Multivariate (PCa FH, 25-Gene) Multivariate (age, 25-Gene)
  p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI) p value OR (95% CI) AUC (95% CI)
Age 0.02 0.9 (1.0–0.9) 0.606 (0.706–0.506) 0.12 0.9 (1.0–0.7) 0.13 0.9 (1.0–0.8)
PCa FH 0.28 2.0 (6.6–0.6) 0.363 (0.448–0.278) 0.23 5.0 (67.1–0.4) 0.27 3.9 (45.6–0.3)
25-Gene < 0.0001 3690.0 (33,894.8–401.7) 0.985 (1.013–0.957) < 0.0001 5760.4 (74,490.3–445.5) < 0.0001 4080.0 (39,436.1–422.1) < 0.0001 4530.3 (48,645.8–421.9)
Combo < 0.0001 3690.0 (33,894.8–401.7) 0.987 (1.013–0.961) < 0.0001 3690.0 (33,894.8–401.7) 0.987 (1.013–0.961) < 0.0001 3690.0 (33,894.8–401.7) 0.986 (1.013–0.959)
  1. 25-Gene 25-Gene Panel, OR odds ratio, AUC area under the ROC curve, CI confidence interval, PSA-4 PSA at 4 ng/mL cutoff, FH family history, Combo combination
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