Table 5 Comparison of diagnostic performance of PSA, PSA at 4 ng/mL cutoff, age, and the 25-Gene Panel urine test and their combinations for PCa diagnosis in the PSA Cohort

36.3% (43.1–29.5%)

92.3% (94.8–88.8%)

80.5% (88.8–72.1%)

62.5% (67.7–57.3%)

6.7 (12.2–3.9)

0.710 (0.759–0.661)

83.9% (89.1–78.8%)

30.2% (36.2–24.1%)

51.1% (56.6–45.6%)

68.4% (77.6–59.2%)

2.3 (3.7–1.4)

0.588 (0.642–0.534)

1.0% (2.5–0.4%)

97.8% (99.7–95.8%)

28.6% (62.0–4.9%)

53.3% (58.2–48.5%)

0.5 (2.4–0.1)

0.516 (0.572–0.460)

88.6% (93.1–84.1%)

93.2% (96.6–90.0%)

91.9% (95.9–88.0%)

90.4% (94.2–86.6%)

107.3 (213.2–54.0)

0.939 (0.962–0.916)

94.8% (98.0–91.7%)

91.4% (95.1–87.8%)

90.6% (94.6–86.6%)

95.3% (98.2–92.5%)

195.5 (431.4–88.6)

0.961 (0.980–0.942)

88.6% (93.1–84.1%)

93.2% (96.6–90.0%)

91.9% (95.9–88.0%)

90.4% (94.2–86.6%)

107.3 (213.2–54.0)

0.942 (0.965–0.919)

94.8% (97.9–91.7%)

91.4% (95.1–87.8%)

90.6% (94.6-86.5%)

95.3% (98.2–94.5%)

194.5 (429.1–88.1)

0.967 (0.984–0.950)

88.5% (93.1–84.0%)

93.2% (96.6–89.9%)

91.9% (95.8–88.0%)

90.4% (94.2–86.6%)

106.6 (212.0–53.7)

0.927 (0.953–0.901)