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Fig. 7 | BMC Medicine

Fig. 7

From: Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancer

Fig. 7

Comparison of cisplatin and carboplatin exposure on germ cell populations of the human foetal testis. Quantification of germ cell subpopulations in the human foetal testis 72 h (ac) and 240 h (df) following exposure to vehicle (VEH), cisplatin (CIS; 0.5 μg/ml) or carboplatin (CARBO; 5 μg/ml). At 72 h post-exposure, gonocytes were significantly reduced for cisplatin only. At 240 h post exposure, a decrease in gonocytes and total germ cells was observed following exposure to either cisplatin or carboplatin. Data analysed using two-way ANOVA. *p < 0.05, **p < 0.01 and ****p < 0.0001. Values shown are means ± SEM and each set of data point represents an individual foetus (n = 6)

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