Fig. 7From: Cisplatin and carboplatin result in similar gonadotoxicity in immature human testis with implications for fertility preservation in childhood cancerComparison of cisplatin and carboplatin exposure on germ cell populations of the human foetal testis. Quantification of germ cell subpopulations in the human foetal testis 72 h (a–c) and 240 h (d–f) following exposure to vehicle (VEH), cisplatin (CIS; 0.5 μg/ml) or carboplatin (CARBO; 5 μg/ml). At 72 h post-exposure, gonocytes were significantly reduced for cisplatin only. At 240 h post exposure, a decrease in gonocytes and total germ cells was observed following exposure to either cisplatin or carboplatin. Data analysed using two-way ANOVA. *p < 0.05, **p < 0.01 and ****p < 0.0001. Values shown are means ± SEM and each set of data point represents an individual foetus (n = 6)Back to article page