Targeting body composition in an older population: do changes in movement behaviours matter? Longitudinal analyses in the PREDIMED-Plus trial

Table 3 Isotemporal substitution of inactive time (30 min/day) with time in bed and physical activity measured with an accelerometer in body composition changes: longitudinal analyses in completers-only

	Percentage of body fat		VAT (g)		Percentage of muscle mass		Muscle-to-fat mass ratio
	β (95% CI)	p value	β (95% CI)	p value	β (95% CI)	p value	β (95% CI)	p value
Inactive time with time in bed
Minimally-adjusted	− 0.10 (− 0.20; 0.00)	0.051	− 26.9 (− 46.5; − 7.27)	0.007	0.09 (− 0.01; 0.19)	0.067	0.93 (0.03; 1.83)	0.042
Multivariable-adjusted	− 0.09 (− 0.19; 0.01)	0.079	− 23.8 (− 43.3; − 4.27)	0.017	0.08 (− 0.02; 0.18)	0.097	0.89 (− 0.01; 1.79)	0.052
Inactive time with LPA
Minimally-adjusted	− 0.13 (− 0.25; − 0.00)	0.044	− 11.8 (− 36.1; 12.6)	0.343	0.12 (0.00; 0.24)	0.046	0.87 (− 0.24; 1.97)	0.124
Multivariable-adjusted	− 0.13 (− 0.25; − 0.00)	0.042	− 11.2 (− 35.4; 13.0)	0.363	0.12 (0.00; 0.25)	0.042	0.90 (− 0.20; 2.01)	0.110
Inactive time with MVPA
Minimally-adjusted	− 0.53 (− 0.76; − 0.29)	< 0.001	− 98.7 (− 146; − 52.0)	< 0.001	0.50 (0.27; 0.73)	< 0.001	3.51 (1.43; 5.60)	0.001
Multivariable-adjusted	− 0.54 (− 0.78; − 0.31)	< 0.001	− 92.4 (− 139; − 45.6)	< 0.001	0.51 (0.28; 0.74)	< 0.001	3.74 (1.64; 5.85)	< 0.001

The values show the β coefficients (95% CIs). These represent the change in outcome variables when substituting 30 min/day of inactive time with time in bed and physical activity. Isotemporal mixed-effects linear models with random intercepts at recruiting centre, family and patient level were used. Analyses included only completers. Minimally-adjusted model: age, sex, intervention arm, time and total wear time. The multivariable-adjusted model was further adjusted for baseline variables, such as educational level, smoking, diabetes, height, and repeatedly measured total energy intake. The n of each outcome at baseline was for the percentage of body fat n = 388, for VAT n = 380, for the percentage of muscle mass n = 388 and for muscle-to-fat mass ratio n = 388; at 6 months was for the percentage of body fat n = 262, for VAT n = 255, for the percentage of muscle mass n = 262 and for muscle-to-fat mass ratio n = 262; at 12 months was for the percentage of body fat n = 303, for VAT n = 299, for the percentage of muscle mass n = 303 and for muscle-to-fat mass ratio n = 303
VAT visceral adipose tissue, LPA light physical activity, MVPA moderate-vigorous physical activity

ISSN: 1741-7015