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Table 1 The clustering status of TB cases by risk factor in England, Wales and Northern Ireland, 2010–2014

From: The impact of HIV infection on tuberculosis transmission in a country with low tuberculosis incidence: a national retrospective study using molecular epidemiology

 

Total cases

Clustered cases (%)

Subsequent cases (% of clustered cases)

First cases (% of clustered cases)

HIV status

 Negative

18,105

10,299 (56.9)

8160 (79.2)

2139 (20.8)

 Positive

759

410 (54.0)

311 (75.9)

99 (24.1)

Year of TB notification

 2010

3174

1795 (56.6)

874 (48.7)

921 (51.3)

 2011

4296

2443 (56.9)

1786 (73.1)

657 (26.9)

 2012

4327

2525 (58.4)

2150 (85.1)

375 (14.9)

 2013

3696

2130 (57.6)

1940 (91.1)

190 (8.9)

 2014

3371

1816 (53.9)

1721 (94.8)

95 (5.2)

Sex

 Female

7521

4153 (55.2)

3272 (78.8)

881 (21.2)

 Male

11,323

6547 (57.8)

5196 (79.4)

1351 (20.6)

 Missing

20

9 (45.0)

3 (33.3)

6 (66.7)

Age (years)

 15–24

3238

2059 (63.6)

1652 (80.2)

407 (19.8)

 25–34

5632

3139 (55.7)

2453 (78.1)

686 (21.9)

 35–44

3578

2041 (57.0)

1601 (78.4)

440 (21.6)

 45–54

2388

1423 (59.6)

1149 (80.7)

274 (19.3)

 55–64

1488

890 (59.8)

717 (80.6)

173 (19.4)

 65+

2540

1157 (45.6)

899 (77.7)

258 (22.3)

Ethnicity

 White

3991

2442 (61.2)

1959 (80.2)

483 (19.8)

 Black African

3211

2031 (63.3)

1603 (78.9)

428 (21.1)

 Black Other

588

458 (77.9)

391 (85.4)

67 (14.6)

 Indian sub-continent

8079

4198 (52.0)

3300 (78.6)

898 (21.4)

 Mixed/other

2525

1330 (52.7)

1029 (77.4)

301 (22.6)

 Missing

470

250 (53.2)

189 (75.6)

61 (24.4)

Time since entry to the UK

 UK born

4431

3000 (67.7)

2495 (83.2)

505 (16.8)

 Within 2 years

2535

1313 (51.8)

979 (74.6)

334 (25.4)

 2–5 years

2999

1509 (50.3)

1154 (76.5)

355 (23.5)

 5–10 years

2743

1485 (54.1)

1149 (77.4)

336 (22.6)

 More than 10 years

4115

2329 (56.6)

1870 (80.3)

459 (19.7)

 Missing

2041

1073 (52.6)

824 (76.8)

249 (23.2)

TB lineage

 Beijing

1041

770 (74.0)

667 (86.6)

103 (13.4)

 Euro-American

7313

4300 (58.8)

3352 (78.0)

948 (22.0)

 Central Asian Strain

5280

3285 (62.2)

2674 (81.4)

611 (18.6)

 East Asian Indian

2674

1046 (39.1)

769 (73.5)

277 (26.5)

 Other/unknown

2554

1306 (51.1)

1008 (77.2)

298 (22.8)

 Missing

2

   

IMD decile

 1

3933

2360 (60.0)

1868 (79.2)

492 (20.8)

 2

3645

2130 (58.4)

1678 (78.8)

452 (21.2)

 3

3008

1704 (56.6)

1334 (78.3)

370 (21.7)

 4

2301

1314 (57.1)

1066 (81.1)

248 (18.9)

 5

1655

906 (54.7)

695 (76.7)

211 (23.3)

 6

1183

652 (55.1)

516 (79.1)

136 (20.9)

 7

838

453 (54.1)

375 (82.8)

78 (17.2)

 8

728

398 (54.7)

302 (75.9)

96 (24.1)

 9

610

307 (50.3)

241 (78.5)

66 (21.5)

 10

474

243 (51.3)

194 (79.8)

49 (20.2)

 Missing

489

242 (49.5)

202 (83.5)

40 (16.5)

Drug misuse

 No

16,536

9241 (55.9)

7291 (78.9)

1950 (21.1)

 Yes

702

551 (78.5)

473 (85.8)

78 (14.2)

 Missing

1626

917 (56.4)

707 (77.1)

210 (22.9)

Alcohol misuse

 No

16,260

9160 (56.3)

7251 (79.2)

1909 (20.8)

 Yes

776

528 (68.0)

441 (83.5)

87 (16.5)

 Missing

1828

1021 (55.9)

779 (76.3)

242 (23.7)

Homelessness

 No

16,771

9480 (56.5)

7500 (79.1)

1980 (20.9)

 Yes

666

449 (67.4)

372 (82.9)

77 (17.1)

 Missing

1427

780 (54.7)

599 (76.8)

181 (23.2)

Imprisonment

 No

16,210

9097 (56.1)

7200 (79.1)

1897 (20.9)

 Yes

649

484 (74.6)

410 (84.7)

74 (15.3)

 Missing

2005

1128 (56.3)

861 (76.3)

267 (23.7)

Site of TB disease/smear status†

 Pulmonary, smear positive

4959

3137 (63.3)

2448 (78.0)

689 (22.0)

 Pulmonary, smear negative/unknown

6952

4084 (58.7)

3279 (80.3)

805 (19.7)

 Extra-pulmonary

6947

3486 (50.2)

2742 (78.7)

744 (21.3)

 Missing

6

2 (33.3)

2 (100.0)

0 (0.0)

  1. IMD: index of multiple deprivation score. IMD score deciles represent relative levels of deprivation of income, employment, health, education, housing and services, crime and living environment for small areas in England and Wales, where 1 = most deprived and 10 = least deprived [29, 30]
  2. †Patients with both pulmonary and extra-pulmonary disease were classed as having pulmonary disease