Skip to main content

Table 3 Prospective associations of log2 MMA, eGFR, and their interaction term, with all-cause mortality

From: Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study

  Model 1 Model 2 Model 3
HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Log2 MMA (nmol/L) 13.33 (3.87–45.91) < 0.001 15.24 (4.47–52.03) < 0.001 11.48 (3.32–39.64) < 0.001
eGFR (10 mL/min/m2) 7.36 (1.98–27.41) 0.003 9.79 (2.61–36.70) 0.001 7.57 (1.98–28.94) 0.003
Log2 MMA × eGFR 0.76 (0.65–0.89) 0.001 0.74 (0.64–0.87) < 0.001 0.77 (0.65–0.90) 0.001
  1. Model 1: log2 MMA, eGFR, log2 MMA × eGFR
  2. Model 2: adjusted for age and sex
  3. Model 3: as model 2 + SES, smoking, alcohol intake, BMI, SBP, vitamin B12, and use of vitamin supplements
  4. Nevents/ntotal = 72/1533
  5. BMI body mass index, eGFR estimated glomerular filtration rate, SBP systolic blood pressure, SES socioeconomic status