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Table 3 Prospective associations of log2 MMA, eGFR, and their interaction term, with all-cause mortality

From: Methylmalonic acid, vitamin B12, renal function, and risk of all-cause mortality in the general population: results from the prospective Lifelines-MINUTHE study

 

Model 1

Model 2

Model 3

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

Log2 MMA (nmol/L)

13.33 (3.87–45.91)

< 0.001

15.24 (4.47–52.03)

< 0.001

11.48 (3.32–39.64)

< 0.001

eGFR (10 mL/min/m2)

7.36 (1.98–27.41)

0.003

9.79 (2.61–36.70)

0.001

7.57 (1.98–28.94)

0.003

Log2 MMA × eGFR

0.76 (0.65–0.89)

0.001

0.74 (0.64–0.87)

< 0.001

0.77 (0.65–0.90)

0.001

  1. Model 1: log2 MMA, eGFR, log2 MMA × eGFR
  2. Model 2: adjusted for age and sex
  3. Model 3: as model 2 + SES, smoking, alcohol intake, BMI, SBP, vitamin B12, and use of vitamin supplements
  4. Nevents/ntotal = 72/1533
  5. BMI body mass index, eGFR estimated glomerular filtration rate, SBP systolic blood pressure, SES socioeconomic status
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BMC Medicine

ISSN: 1741-7015

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