Table 2 The diagnostic performance for detecting pathological HSIL+ at different hypothetical biopsy thresholds
| Â | Accuracy, % (95% CI) | Sensitivity, % (95% CI) | Specificity, % (95% CI) | Positive predictive, value % (95% CI) | Negative predictive, value % (95% CI) |
|---|---|---|---|---|---|
Analysis of images alone by CAIADS | |||||
 Normal/benign versus low-grade or worse | 63.6 (62.1–65.1) | 87.3 (85.5–88.9) | 48.9 (46.8–50.9) | 51.6 (49.6–53.6) | 86.0 (84.1–87.8) |
 Less severe impressionsa versus high-grade or worse | 80.7 (79.4–81.9) | 65.8 (63.3–68.2) | 90.0 (88.7–91.2) | 80.4 (78.0–82.6) | 80.8 (79.3–82.3) |
Analysis of both images and non-image informationb by CAIADS | |||||
 Normal/benign versus low-grade or worse | 66.7 (65.2–68.2) | 90.5 (88.9–91.4) | 51.8 (49.8–53.8) | 54.0 (52.0–55.9) | 89.7 (88.0–91.3) |
 Less severe impressionsa versus high-grade or worse | 85.5 (84.3–86.6) | 71.9 (69.5–74.2) | 93.9 (92.9–94.9) | 88.1 (86.2–89.9) | 84.3 (82.8–85.6) |
Analysis of both images and non-image informationb by colposcopists | |||||
 Normal/benign versus low-grade or worse | 64.1 (62.6–65.6) | 83.5 (81.5–85.3) | 52.0 (50.0–54.1) | 52.1 (50.0–54.1) | 83.5 (81.5–85.3) |
 Less severe impressionsa versus high-grade or worse | 81.6 (80.4–82.8) | 60.4 (57.9–62.9) | 94.9 (93.9–95.7) | 88.0 (85.9–89.9) | 79.3 (77.8–80.8) |