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Table 4 Difference in longitudinal BMI change from baseline (age 1) stratified by PCOS diagnostic criteria

From: Updated adolescent diagnostic criteria for polycystic ovary syndrome: impact on prevalence and longitudinal body mass index trajectories from birth to adulthood

Original Rotterdam criteria
  Original non-PCOS (n = 161) Original PCOS (n = 66) Difference between the groups p value*
∆BMI 95% CI ∆BMI 95% CI ∆BMI 95% CI
Age 1 (baseline)  
Age 2 − 1.31 − 2.14 to − 0.47 − 2.72 − 4.78 to − 0.65 − 1.47 − 3.32 to 0.37 0.117
Age 3 − 0.93 − 1.49 to − 0.37 − 1.19 − 2.63 to 0.25 − 0.27 − 1.53 to 1.00 0.680
Age 5 − 1.21 − 1.72 to − 0.69 − 1.35 − 2.68 to − 0.02 − 0.15 − 1.33 to 1.02 0.800
Age 8 − 0.18 − 0.70 to 0.34 − 0.25 − 1.57 to 1.07 − 0.08 − 1.25 to 1.09 0.895
Age 10 1.18 0.67 to 1.69 1.82 0.50 to 3.14 0.64 − 0.53 to 1.80 0.284
Age 14 4.24 3.73 to 4.75 5.83 4.52 to 7.14 1.59 0.43 to 2.75 0.007
Age 16 5.77 5.25 to 6.29 7.41 6.07 to 8.75 1.64 0.46 to 2.82 0.006
Age 20 6.85 6.33 to 7.37 7.94 6.59 to 9.29 1.10 − 0.09 to 2.29 0.070
Age 22 7.39 6.87 to 7.91 9.40 8.07 to 10.72 2.00 0.82 to 3.17 0.001
Updated 2018 adolescent Rotterdam criteria
  Updated non-PCOS (n = 190) Updated PCOS (n = 37) Difference between the groups p value*
∆BMI 95% CI ∆BMI 95% CI ∆BMI 95% CI
Age 1 (baseline)  
Age 2 − 1.43 − 2.21 to − 0.65 − 2.57 − 5.63 to 0.49 − 1.27 − 3.43 to 0.89 0.248
Age 3 − 0.95 − 1.45 to − 0.44 − 1.86 − 4.38 to 0.67 − 0.96 − 2.68 to 0.77 0.278
Age 5 − 1.28 − 1.75 to − 0.80 − 1.02 − 3.21 to 1.17 0.23 − 1.28 to 1.73 0.770
Age 8 − 0.26 − 0.74 to 0.21 0.32 − 1.81 to 2.45 0.56 − 0.91 to 2.03 0.457
Age 10 1.14 0.67 to 1.61 2.73 0.57 to 4.89 1.55 0.07 to 3.04 0.041
Age 14 4.22 3.75 to 4.69 7.51 5.38 to 9.64 3.27 1.80 to 4.74 < 0.001
Age 16 5.70 5.22 to 6.17 9.60 7.41 to 11.79 3.86 2.35 to 5.37 < 0.001
Age 20 6.70 6.22 to 7.18 10.20 7.97 to 12.42 3.50 1.98 to 5.04 < 0.001
Age 22 7.27 6.79 to 7.74 12.17 10.01 to 14.33 4.89 3.40 to 6.39 < 0.001
  1. Models were generated using generalized estimating equations and adjusted for age of menarche, family income at age 14, smoking status at age 22, and marital status at age 22
  2. *p value for the interaction term PCOS status by age
  3. ∆BMI mean BMI change, CI confidence interval, PCOS polycystic ovary syndrome