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Table 4 Difference in longitudinal BMI change from baseline (age 1) stratified by PCOS diagnostic criteria

From: Updated adolescent diagnostic criteria for polycystic ovary syndrome: impact on prevalence and longitudinal body mass index trajectories from birth to adulthood

Original Rotterdam criteria

 

Original non-PCOS (n = 161)

Original PCOS (n = 66)

Difference between the groups

p value*

∆BMI

95% CI

∆BMI

95% CI

∆BMI

95% CI

Age 1 (baseline)

–

–

–

–

–

–

 

Age 2

− 1.31

− 2.14 to − 0.47

− 2.72

− 4.78 to − 0.65

− 1.47

− 3.32 to 0.37

0.117

Age 3

− 0.93

− 1.49 to − 0.37

− 1.19

− 2.63 to 0.25

− 0.27

− 1.53 to 1.00

0.680

Age 5

− 1.21

− 1.72 to − 0.69

− 1.35

− 2.68 to − 0.02

− 0.15

− 1.33 to 1.02

0.800

Age 8

− 0.18

− 0.70 to 0.34

− 0.25

− 1.57 to 1.07

− 0.08

− 1.25 to 1.09

0.895

Age 10

1.18

0.67 to 1.69

1.82

0.50 to 3.14

0.64

− 0.53 to 1.80

0.284

Age 14

4.24

3.73 to 4.75

5.83

4.52 to 7.14

1.59

0.43 to 2.75

0.007

Age 16

5.77

5.25 to 6.29

7.41

6.07 to 8.75

1.64

0.46 to 2.82

0.006

Age 20

6.85

6.33 to 7.37

7.94

6.59 to 9.29

1.10

− 0.09 to 2.29

0.070

Age 22

7.39

6.87 to 7.91

9.40

8.07 to 10.72

2.00

0.82 to 3.17

0.001

Updated 2018 adolescent Rotterdam criteria

 

Updated non-PCOS (n = 190)

Updated PCOS (n = 37)

Difference between the groups

p value*

∆BMI

95% CI

∆BMI

95% CI

∆BMI

95% CI

Age 1 (baseline)

–

–

–

–

–

–

 

Age 2

− 1.43

− 2.21 to − 0.65

− 2.57

− 5.63 to 0.49

− 1.27

− 3.43 to 0.89

0.248

Age 3

− 0.95

− 1.45 to − 0.44

− 1.86

− 4.38 to 0.67

− 0.96

− 2.68 to 0.77

0.278

Age 5

− 1.28

− 1.75 to − 0.80

− 1.02

− 3.21 to 1.17

0.23

− 1.28 to 1.73

0.770

Age 8

− 0.26

− 0.74 to 0.21

0.32

− 1.81 to 2.45

0.56

− 0.91 to 2.03

0.457

Age 10

1.14

0.67 to 1.61

2.73

0.57 to 4.89

1.55

0.07 to 3.04

0.041

Age 14

4.22

3.75 to 4.69

7.51

5.38 to 9.64

3.27

1.80 to 4.74

< 0.001

Age 16

5.70

5.22 to 6.17

9.60

7.41 to 11.79

3.86

2.35 to 5.37

< 0.001

Age 20

6.70

6.22 to 7.18

10.20

7.97 to 12.42

3.50

1.98 to 5.04

< 0.001

Age 22

7.27

6.79 to 7.74

12.17

10.01 to 14.33

4.89

3.40 to 6.39

< 0.001

  1. Models were generated using generalized estimating equations and adjusted for age of menarche, family income at age 14, smoking status at age 22, and marital status at age 22
  2. *p value for the interaction term PCOS status by age
  3. ∆BMI mean BMI change, CI confidence interval, PCOS polycystic ovary syndrome