Reduced growth velocity from the mid-trimester is associated with placental insufficiency in fetuses born at a normal birthweight

Table 2 Relative risk of indicators of placental insufficiency when a 20–36-week EFW and AC growth velocity cut-off of < − 30 centiles is used to dichotomise the cohort

	Growth parameter	Low growth velocity n (%)	Growth velocity not low n (%)	RR (95% CI) if low 20–36-week growth velocity of < − 30 centiles	P
CPR < 5th centile [12]	EFW	11/65 (16.9)	18/237 (7.6)	2.23 (1.11–4.36)	0.03
Umbilical artery pH < 7.15 at birth	EFW	9/48 (18.8)	15/190 (7.9)	2.38 (1.11–4.93)	0.03
Umbilical artery pH < 7.15 at birth	AC	5/18 (27.8)	19/220 (8.6)	3.22 (1.32–6.93)	0.02
ADP low body fat percentage [13]	AC	1/9 (11.1)	11/127 (8.7)	1.28 (0.22–5.87)	0.58
Placental weight < 10th centile [21]	EFW	27/61 (44.3)	36/216 (16.7)	2.66 (1.75–3.96)	< 0.0001
Placental weight < 10th centile [21]	AC	10/22 (45.5)	53/255 (20.8)	2.19 (1.24–3.44)	0.01

RR relative risk, CI confidence interval, EFW estimated fetal weight, AC abdominal circumference, CPR cerebroplacental ratio, ADP air displacement plethysmography

ISSN: 1741-7015