| Hazard ratio (95% CI) | |||
---|---|---|---|---|
Fit | Pre-frail | Mild-moderate frailty | Severe frailty | |
Primary endpoints | ||||
 Time to first adjudicated stroke or systemic embolism | ||||
  Unadjusted | 1 | 1.22 (1.03–1.45) | 1.93 (1.59–2.35) | 1.58 (0.99–2.55) |
  Adjusted | 1 | 1.22 (0.90–1.65) | 1.84 (1.31–2.59) | 2.30 (1.17–4.52) |
 Time to adjudicated major bleeding during treatment | ||||
  Unadjusted | 1 | 1.22 (1.04–1.43) | 1.75 (1.46–2.09) | 3.02 (2.17–4.20) |
  Adjusted | 1 | 1.32 (1.04–1.68) | 1.79 (1.36–2.37) | 2.86 (1.72–4.76) |
Composite net clinical endpoints | ||||
 Stroke, systemic embolic event, major bleeding, or death | ||||
  Unadjusted | 1 | 1.30 (1.19–1.43) | 2.31 (2.09–2.55) | 3.29 (2.74–3.96) |
  Adjusted | 1 | 1.49 (1.28–1.74) | 2.45 (2.07–2.90) | 3.56 (2.63–4.81) |
 Disabling stroke, life-threatening bleeding, or death | ||||
  Unadjusted | 1 | 1.37 (1.22–1.53) | 2.60 (2.30–2.94) | 3.69 (2.96–4.59) |
  Adjusted | 1 | 1.60 (1.32–1.95) | 2.88 (2.33–3.55) | 4.59 (3.24–6.50) |
 Stroke, systemic embolic event, life-threatening bleeding, or death | ||||
  Unadjusted | 1 | 1.32 (1.19–1.47) | 2.49 (2.22–2.78) | 3.36 (2.73–4.14) |
  Adjusted | 1 | 1.56 (1.30–1.87) | 2.73 (2.24–3.33) | 4.24 (3.04–5.91) |
Death | ||||
 Unadjusted | 1 | 1.40 (1.24–1.58) | 2.75 (2.41–3.13) | 3.94 (3.13–4.97) |
 Adjusted | 1 | 1.68 (1.36–2.09) | 3.13 (2.48–3.95) | 4.97 (3.42–7.23) |