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Table 5 The C-indices for testing of the VitaL CLASS score and other pre-existing scoring systems

From: Development and validation of the VitaL CLASS score to predict mortality in stage IV solid cancer patients with septic shock in the emergency department: a multi-center, prospective cohort study

Scoring system Development set Validation set
AIC C-index (95% CI) p value AIC C-index (95% CI) p value
VitaL CLASS score 1287.4 0.808 (0.772–0.845) Reference 1299.1 0.736 (0.694–0.778) Reference
SOFA score 1362.0 0.713 (0.664–0.762) 0.001 1347.2 0.656 (0.603–0.708) 0.01
APACHE II score 1370.3 0.692 (0.643–0.741) < 0.001 1329.1 0.682 (0.633–0.731) 0.08
Quick SOFA score 1419.2 0.614 (0.565–0.663) < 0.001 1380.4 0.552 (0.502–0.601) < 0.001
NEWS 1399.2 0.669 (0.617–0.720) < 0.001 1379.3 0.561 (0.509–0.613) < 0.001
MEWS 1435.5 0.554 (0.501–0.607) < 0.001 1383.6 0.486 (0.433–0.540) < 0.001
  1. AIC Akaike information criterion, APACHE Acute Physiology and Chronic Health Evaluation, CI confidence interval, MEWS Modified Early Warning Score, NEWS National Early Warning Score, SOFA Sequential Organ Failure Assessment, VitaL CLASS vital signs-lung cancer-lactate-albumin in septic shock