N = 309,123. Number used for analysis N = 286,115 (92.6%) used for analysis after excluding missing values. | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Alcohol consumed with/without food | All-cause mortality | MACE | Liver cirrhosis | Accidents/self-harm/assaults | New cancer (all-cause) incidence | Alcohol cancer incidence | ||||||
Events = 8869 (2.9%) | HR with 95% CI; p value | Events = 5246 (1.7%) | HR with 95% CI; p value | Events = 838 (0.3%) | HR with 95% CI; p value | Events = 16,818 (5.4%) | HR with 95% CI; p value | Events = 27,543 (8.9%) | HR with 95% CI; p value | Events = 6529 (2.1%) | HR with 95% CI; p value | |
Yes (reference) N = 133,545 (43.2%) | 3289 (2.5%) | 1 | 1937 (1.4%) | 1 | 228 (0.2%) | 1 | 6819 (5.1%) | 1 | 12,441 (9.3%) | 1 | 3100 (2.3%) | 1 |
No N = 63,514 (20.6%) | 2603 (4.1%) | 1.10 (1.02–1.17); p = 0.01 | 1482 (2.3%) | 1.08 (0.99–1.17); p = 0.09 | 304 (0.5%) | 0.88 (0.71–1.11); p = 0.29 | 4004 (6.3%) | 1.03 (0.98–1.08); p = 041 | 5551 (8.7%) | 0.96 (0.92–1.00); p = 0.05 | 1173 (1.8%) | 0.94 (0.87–1.02); p = 0.14 |
Mixed N = 112,064 (36.2%) | 2977 (2.7%) | 1.01 (0.96–1.07); p = 0.75 | 1827 (1.6%) | 1.01 (0.94–1.09); p = 0.77 | 306 (0.3%) | 1.00 (0.82–1.22); p = 0.96 | 5995 (5.3%) | 1.00 (0.97–1.04); p = 0.82 | 9551 (8.5%) | 1.00 (0.97–1.03); p = 0.96 | 2256 (2%) | 0.98 (0.92–1.04); p = 0.50 |
Global p value for heterogeneity | – | < 0.01 | – | < 0.01 | – | < 0.01 | – | < 0.01 | – | < 0.01 | – | 0.03 |