Table 4 Alcohol consumption frequency and adjusted risk for poor clinical outcomes, stratified sub-groups based on average alcohol consumption
N = 309,123. Number used for analysis N = 286,115 (92.6%) used for analysis after excluding missing values | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Type of alcohol consumed | All-cause mortality | MACE | Liver Cirrhosis | Accidents/self-harm/assaults | New cancer (all-cause) incidence | Alcohol cancer incidence | ||||||
Events = 8869 (2.9%) | HR with 95% CI | Events = 5246 (1.7%) | HR with 95% CI | Events = 838 (0.3%) | HR with 95% CI | Events = 16,818 (5.4%) | HR with 95% CI | Events = 27,543 (8.9%) | HR with 95% CI | Events = 6529 (2.1%) | HR with 95% CI | |
3–4 times/week (reference) N = 103,717 (33.5%) | 2598 (2.5%) | 1 | 1603 (1.5%) | 1 | 180 (0.2%) | 1 | 5336 (5.1%) | 1 | 8996 (8.7%) | 1 | 2144 (2.1%) | 1 |
1–2 times/week N = 115,270 (37.3%) | 3084 (2.7%) | 1.09 (1.03–1.16); p < 0.01 | 1921 (1.7%) | 1.14 (1.06–1.23); p < 0.01 | 188 (0.2%) | 1.04 (0.83–1.31); p = 0.69 | 6153 (5.3%) | 1.04 (1.00–1.09); p = 0.04 | 9612 (8.3%) | 1.02 (0.99–1.05); p = 0.17 | 2376 (2.1%) | 1.01 (0.95–1.08); p = 0.73 |
Daily or almost daily N = 90,136 (29.2%) | 3187 (3.5%) | 1.06 (0.99–1.12); p = 0.052 | 1722 (1.9%) | 0.99 (0.91–1.07); p = 0.80 | 470 (0.5%) | 1.49 (1.21–1.82); p < 0.01 | 5329 (5.9%) | 1.02 (0.97–1.06); p = 0.43 | 8935 (9.9%) | 0.99 (0.96–1.02); p = 0.65 | 2009 (2.2%) | 0.98 (0.87–1.02); p = 0.50 |
Global p value for heterogeneity | – | < 0.01 | – | < 0.01 | – | < 0.01 | – | < 0.01 | – | < 0.01 | – | 0.03 |