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Table 2 Association between any-cause mortality and comorbidity cluster

From: Model-based comorbidity clusters in patients with heart failure: association with clinical outcomes and healthcare utilization

 

Low-burden

Metabolic-vascular

Ischemic

Anemia

Metabolic

Overall

 

N = 83,577

N = 73,284

N = 83,283

N = 14,959

N = 63,281

N = 318,030

Deaths, n (%)

18,497 (22.2%)

17,943 (24.5%)

32,709 (39.3%)

4615 (30.9%)

8774 (13.9%)

82,538 (26%)

Person-months

3,666,146

2,270,448

3,246,368

545,985

2,334,907

12,063,855

Deaths per 1000 person-months (95% CI)

5.05 (4.97–5.12)

7.9 (7.8–8.02)

10.08 (9.96–10.18)

8.45 (8.21–8.70)

3.76 (3.68–3.84)

6.84 (6.80–6.89)

Model 1a

N = 77,325

N = 68,414

N = 77,425

N = 13,850

N = 58,635

N = 295,649

Deaths, n (%)

17,291 (22.4%)

16,414 (24.7%)

30,510 (39.4%)

4325 (31.2%)

8251 (14.1%)

77,276 (26.1%)

Adjusted HRa (95% CI)

1.00 (Ref)

1.87 (1.74–2.01)

1.24 (1.16–1.33)

1.46 (1.30–1.64)

1.18 (1.09–1.29)

 

Model 2b

2707

3267

3265

247

2483

N = 12,091

Deaths, n (%)

510 (20.1%)

755 (24.6%)

1166 (38%)

98 (28.3%)

281 (12.1%)

3478 (28.8%)

Adjusted HRb (95% CI)

1.00 (Ref)

1.60 (1.44, 1.79)

1.62 (1.47, 1.80)

1.60 (1.30, 1.96)

0.96 (0.84, 1.10)

 
  1. Abbreviations: CI confidence interval, HR hazard ratio, ref. reference
  2. aAdjusted for age, sex, race, education, medical insurance status, whether diagnosis was gained inpatient or in outpatient and HF medications; time-varying coefficient model; excludes patients with missing data on race (21,557) and education (2097)
  3. bAdjusted for age, sex, race, education, medical insurance status, whether diagnosis was gained inpatient or in outpatient, HF medications, ejection fraction, smoking status; proportional hazards met; excludes patients with missing data on race (21,557), education (2097), ejection fraction (304,477), and smoking status (282,333)