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Table 3 Association between rs1990622 variant T allele and TMEM106B expression

From: rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues

Dataset

Beta

SE

P value

Brain tissue

Number

UKBEC

0.024

0.046

5.96E−01

Cerebellar cortex

134

UKBEC

0.019

0.053

7.20E−01

Frontal cortex

134

UKBEC

0.037

0.054

4.92E−01

Hippocampus

134

UKBEC

6.57E−05

0.044

9.99E−01

Medulla

134

UKBEC

0.015

0.065

8.19E−01

Occipital cortex

134

UKBEC

− 0.003

0.063

9.63E−01

Putamen

134

UKBEC

− 0.025

0.058

6.69E−01

Substantia nigra

134

UKBEC

− 0.030

0.049

5.38E−01

Temporal cortex

134

UKBEC

− 0.019

0.058

7.48E−01

Thalamus

134

UKBEC

0.046

0.052

3.78E−01

Intralobular white matter

134

GTEx

− 0.084

0.065

1.90E−01

Amygdala

129

GTEx

− 0.100

0.059

9.60E−02

Anterior cingulate cortex

147

GTEx

− 0.025

0.033

4.50E−01

Caudate

194

GTEx

− 0.130

0.041

1.50E−03

Cerebellar hemisphere

175

GTEx

− 0.150

0.031

1.90E−06

Cerebellum

209

GTEx

− 0.140

0.032

2.20E−05

Cortex

205

GTEx

− 0.089

0.039

2.20E−02

Frontal cortex

175

GTEx

− 0.009

0.037

8.20E01

Hippocampus

165

GTEx

− 0.048

0.044

2.80E01

Hypothalamus

170

GTEx

0.048

0.034

1.60E01

Nucleus accumbens

202

GTEx

− 0.022

0.032

5.00E01

Putamen

170

GTEx

− 0.047

0.062

4.50E01

Spinal cord

126

GTEx

0.100

0.067

1.40E01

Substantia nigra

114

Mayo

− 0.036

2.11E01

Cerebellum in AD

186

Mayo

0.052

1.18E01

Cerebellum in non-AD

170

Mayo

− 0.001

9.61E01

Temporal cortex in AD

191

Mayo

0.031

1.75E01

Temporal cortex in non-AD

181

  1. SE standard error. Beta is the regression coefficient based on the effect allele. Beta > 0 and beta < 0 mean that this effect allele could increase and reduce gene expression, respectively. The statistically significant association is defined to be P < 0.05/27 = 1.85E−03. The suggestive association is defined to be P < 0.05