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Table 3 Association between rs1990622 variant T allele and TMEM106B expression

From: rs1990622 variant associates with Alzheimer’s disease and regulates TMEM106B expression in human brain tissues

Dataset Beta SE P value Brain tissue Number
UKBEC 0.024 0.046 5.96E−01 Cerebellar cortex 134
UKBEC 0.019 0.053 7.20E−01 Frontal cortex 134
UKBEC 0.037 0.054 4.92E−01 Hippocampus 134
UKBEC 6.57E−05 0.044 9.99E−01 Medulla 134
UKBEC 0.015 0.065 8.19E−01 Occipital cortex 134
UKBEC − 0.003 0.063 9.63E−01 Putamen 134
UKBEC − 0.025 0.058 6.69E−01 Substantia nigra 134
UKBEC − 0.030 0.049 5.38E−01 Temporal cortex 134
UKBEC − 0.019 0.058 7.48E−01 Thalamus 134
UKBEC 0.046 0.052 3.78E−01 Intralobular white matter 134
GTEx − 0.084 0.065 1.90E−01 Amygdala 129
GTEx − 0.100 0.059 9.60E−02 Anterior cingulate cortex 147
GTEx − 0.025 0.033 4.50E−01 Caudate 194
GTEx − 0.130 0.041 1.50E−03 Cerebellar hemisphere 175
GTEx − 0.150 0.031 1.90E−06 Cerebellum 209
GTEx − 0.140 0.032 2.20E−05 Cortex 205
GTEx − 0.089 0.039 2.20E−02 Frontal cortex 175
GTEx − 0.009 0.037 8.20E01 Hippocampus 165
GTEx − 0.048 0.044 2.80E01 Hypothalamus 170
GTEx 0.048 0.034 1.60E01 Nucleus accumbens 202
GTEx − 0.022 0.032 5.00E01 Putamen 170
GTEx − 0.047 0.062 4.50E01 Spinal cord 126
GTEx 0.100 0.067 1.40E01 Substantia nigra 114
Mayo − 0.036 2.11E01 Cerebellum in AD 186
Mayo 0.052 1.18E01 Cerebellum in non-AD 170
Mayo − 0.001 9.61E01 Temporal cortex in AD 191
Mayo 0.031 1.75E01 Temporal cortex in non-AD 181
  1. SE standard error. Beta is the regression coefficient based on the effect allele. Beta > 0 and beta < 0 mean that this effect allele could increase and reduce gene expression, respectively. The statistically significant association is defined to be P < 0.05/27 = 1.85E−03. The suggestive association is defined to be P < 0.05