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Table 3 Univariable logistic regression model predicting ASQ dimension result below the − 2SD cut-off for 235 toddlers included in the analysis by ZIKV exposure status

From: In utero Zika virus exposure and neurodevelopment at 24 months in toddlers normocephalic at birth: a cohort study

 

OR (95% CI) of ASQ dimension below − 2SD cut-off

 

Characteristic

Communication

P value

Gross motor

P value

Fine motor

P value

Problem solving

P value

Personal-social

P value

ZIKV exposure

 Exposed

0.36 (0.2–0.8)

0.01

0.84 (0.2–3.6)

0.81

0.49 (0.1–2.0)

0.32

2.08 (0.4–10.0)

0.36

0.67 (0.3–1.8)

0.41

 Unexposed

1

 

1

 

1

 

1

 

1

 

Sex

 Male

1

 

1

 

1

 

1

 

1

 

 Female

0.35 (0.2–0.8)

0.01

1.49 (0.4–6.4)

0.59

0.88 (0.2–3.6)

0.85

0.36 (0.1–1.4)

0.15

0.62 (0.2–1.6)

0.31

Education of mother

 Primary

1

0.57

1

0.65

1

0.65

1

0.58

1

0.15

 Secondary

0.76 (0.3–2.3)

 

0.70 (0.1–4.4)

 

0.70 (0.1–4.4)

 

0.30 (0.1–1.9)

 

1.20 (0.2–6.5)

 

 Tertiary

0.54 (0.2–1.6)

 

0.34 (0.1–2.5)

 

0.34 (0.1–2.5)

 

0.45 (0.1–2.1)

 

1.44 (0.3–7.1)

 

 Unknown

1.29 (0.3–6.0)

 

1.25 (0.1–14.9)

 

1.25 (0.1–14.9)

 

0.81 (0.08–8.5)

 

6.36 (1.0–39.6)

 

Education of father

 Primary

1

0.28

1

0.55

1

0.65

1

0.13

1

0.12

 Secondary

0.52 (0.2–1.6)

 

0.56 (0.1–3.6)

 

0.70 (0.1–4.4)

 

0.56 (0.09–3.6)

 

0.49 (0.14–1.7)

 

 Tertiary

0.27 (0.07–1.1)

 

0.23 (0.02–2.6)

 

0.34 (0.05–2.5)

 

0 (0)

 

0.25 (0.05–1.1)

 

 Unknown

0.43 (0.1–1.3)

 

0.28 (0.04–2.1)

 

1.25 (0.1–14.9)

 

0.73 (0.1–4.0)

 

0.20 (0.05–0.8)

 

Languages spoken in the household

 One

1

 

1

 

1

 

1

 

1

 

 More than one

2.00 (0.8–4.9)

0.13

0.98 (0.2–4.2)

0.98

0.58 (0.1–2.4)

0.44

2.43 (0.5–11.7)

0.27

1.00 (0.4–2.7)

0.99

Parity

 0

1

0.08

1

0.75

1

0.44

1

0.31

1

0.89

 1

0.65 (0.2–1.8)

 

0.89 (0.2–5.5)

 

0.53 (0.1–2.8)

 

0.26 (0.03–2.3)

 

1.01 (0.3–3.0)

 

 2

1.29 (0.4–4.4)

 

2.62 (0.4–16.5)

 

0 (0)

 

1.54 (0.3–8.4)

 

0.93 (0.2–4.7)

 

 3+

3.19 (1.1–9.3)

 

1.48 (0.2–14.9)

 

0.87 (0.1–7.8)

 

1.82 (0.3–10.0)

 

1.73 (0.4–7.1)

 

Birth weight

 Low birth weight

1.02 (0.2–4.7)

0.98

9.88 (2.1–45.9)

0.003

2.02 (0.2–17.5)

0.52

0

 

1.70 (0.4–8.1)

0.51

 Normal

1

 

1

 

1

 

1

 

1