Table 1 Characteristics of cases and controls

Length of exposure period (years): median (IQR)

8.1 (5.5, 11.0)

8.1 (5.5, 11.0)

Year of diagnosis/index date: median (IQR)

2005 (2002, 2007)

2005 (2002, 2007)

Age at diagnosis/index date (years)

0–39

1983 (3.2%)

12,004 (4.3%)

40–59

15,087 (24.3%)

86,385 (31.2%)

60–79

35,294 (56.9%)

143,628 (51.9%)

80 +

9655 (15.6%)

34,563 (12.5%)

Deprivation quintile

1 (least deprived)

3911 (6.3%)

17,535 (6.3%)

2

12,427 (20.0%)

55,723 (20.1%)

3

5811 (9.4%)

26,166 (9.5%)

4

15,518 (25.0%)

68,902 (24.9%)

5 (most deprived)

16,558 (26.7%)

73,319 (26.5%)

Missing

117 (0.0%)

529 (0.19%)

Gender

Male

29,653 (47.8%)

128,988 (46.6%)

Female

32,366 (52.2%)

147,592 (53.4%)

Smoking status*

Never smoked

20,982 (33.8%)

105,499 (38.1%)

Ex-smoker

12,792 (20.6%)

50,731 (18.3%)

Current smoker

15,877 (25.6%)

57,734 (20.9%)

Missing

12,368 (19.9%)

62,616 (22.6%)

Alcohol consumption*

Non-drinker

9451 (15.2%)

40,117 (14.5%)

Light/moderate

30,759 (49.6%)

135,074 (48.8%)

Heavy drinker

2799 (4.5%)

10,225 (3.7%)

Missing

19,010 (30.7%)

91,164 (33.0%)

 Diabetes

5428 (8.8%)

20,750 (7.5%)

 Myocardial infarction

4001 (6.5%)

15,045 (5.6%)

 Coronary heart disease

9984 (16.1%)

37,739 (13.6%)

 Heart failure

2155 (3.5%)

7625 (2.8%)

 Peripheral vascular disease

3225 (5.2%)

10,475 (3.8%)

 Dementia

516 (0.8%)

3353 (1.2%)

 Cerebrovascular disease

4372 (7.2%)

16,875 (6.1%)

 Chronic obstructive pulmonary disease

6498 (10.4%)

19,155 (6.9%)

 Osteoporosis

1866 (3.0%)

7421 (2.7%)

 Rheumatology

1578 (2.5%)

6268 (2.3%)

 Renal disease

2513 (4.1%)

8719 (3.2%)

 Liver disease

683 (1.1%)

1973 (0.7%)

 Irritable bowel disease

3533 (5.7%)

15,360 (5.6%)

 Human immunodeficiency virus

17 (0.0%)

41 (0.0%)

 Hemiplegia/paraplegia

307 (0.5%)

1324 (0.5%)