Table 6 Signals associated with decreased cancer risk (exposure: ≥ 6 prescriptions)
Cancer | Adjusted for comorbidities†| Adjusted for comorbidities†and smoking |
|---|---|---|
Breast§ | Carbamazepine (OR = 0.70) Iron (OR = 0.78) Prednisolone (OR = 0.78) Trimethoprim (OR = 0.72) | Iron (OR = 0.72) Trazodone (OR = 0.62) Trimethoprim (OR = 0.71) |
Lung | Benzalkonium* (OR = 0.49) Dimeticone* (OR = 0.46) Levodopa (OR = 0.38) |  |
Colorectal | Diclofenac (OR = 0.71) Lactulose (OR = 0.78) Misoprostol (OR = 0.69) Naproxen (OR = 0.72) Senna (OR = 0.73) | Diclofenac (OR = 0.72) Lactulose (OR = 0.77) Naproxen (OR = 0.71) Oxybutynin (OR = 0.60) |
Prostate§§ | Benzalkonium* (OR = 0.36) Bumetanide (OR = 0.57) Citalopram (OR = 0.59) Dimeticone* (OR = 0.36) Furosemide (OR = 0.70) Iron (OR = 0.72) Lactulose (OR = 0.68) Lidocaine* (OR = 0.35) Risperidone (OR = 0.27) Senna (OR = 0.70) Vitamin D (OR = 0.66) | Calcium (OR = 0.67) Citalopram (OR = 0.53) Furosemide (OR = 0.74) Lactulose (OR = 0.70) Senna (OR = 0.67) Vitamin D (OR = 0.60) |
Bladder | Iron (OR = 0.64) Lactulose (OR = 0.73) | Pantoprazole (OR = 0.27) Sotalol (OR = 0.25) |
Malignant melanoma | Gliclazide (OR = 0.51) | – |
Oesophagus | – | Aspirin high dose (OR = 0.52) |
Non-Hodgkin’s lymphoma | Vitamin B (OR = 0.51) | Vitamin B (OR = 0.51) |
Leukaemia | – | Calcium (OR = 0.56) |
Oral (inc. head, neck, nasal) | – | – |
Stomach | Finasteride (OR = 0.41)§§ | Diclofenac* (OR = 0.18) |
Ovary§ | Nifedipine (OR = 0.56) Progestogen-contraceptive (OR = 0.44) | – |
Kidney | – | Digoxin (OR = 0.43) |
Uterus§ | Estrogen-HRT (OR = 0.68) | – |
Larynx | Diclofenac (OR = 0.48) Doxazosin (OR = 0.31) | – |