Table 3 Results from multivariable Cox regression stratified by study cohort and HF subtype
Variables | Transformation | Coef (SE) | HR (95% CI) | Pinteraction |
|---|---|---|---|---|
Age, year |  | 0.023 (0.004) | 1.02 (1.02–1.03) |  |
COPD |  | 0.298 (0.087) | 1.35 (1.14–1.60) |  |
NYHA class III |  | 0.360 (0.124) | 1.43 (1.12–1.83) |  |
NYHA class IV |  | 0.298 (0.133) | 1.35 (1.04–1.75) |  |
Hemoglobin, mmol/L |  | − 0.164 (0.034) | 0.85 (0.79–0.91) |  |
Sodium, mmol/L |  | − 0.032 (0.009) | 0.97 (0.95–0.99) |  |
BUN, mmol/L | = log2(x*) | 0.335 (0.065) | 1.40 (1.23–1.59) |  |
NT-proBNP, ng/L | = log2(x) | 0.294 (0.035) | 1.34 (1.25–1.44) |  |
SBP (HFrEF), mmHg | = min(x,130)†| − 0.029 (0.003) | 0.97 (0.96–0.98) | < .001 |
SBP (HFmrEF), mmHg | = min(x,130) | − 0.009 (0.008) | 0.99 (0.98–1.01) |  |
SBP (HFpEF), mmHg | = min(x,130) | − 0.006 (0.007) | 0.99 (0.98–1.01) |  |
Creatinine (HFrEF), μmol/L | = log2(x) | 0.037 (0.100) | 1.04 (0.85–1.26) | .010 |
Creatinine (HFmrEF), μmol/L | = log2(x) | − 0.367 (0.140) | 0.69 (0.53–0.91) |  |
Creatinine (HFpEF), μmol/L | = log2(x) | − 0.209 (0.150) | 0.81 (0.54–1.19) |  |
MI (HFrEF) |  | 0.430 (0.097) | 1.54 (1.27–1.86) | .001 |
MI (HFmrEF) |  | − 0.032 (0.188) | 0.97 (0.67–1.40) |  |
MI (HFpEF) |  | − 0.216 (0.201) | 0.79 (0.53–1.17) |  |
Diabetes (HFrEF) |  | 0.265 (0.101) | 1.30 (1.07–1.59) | .041 |
Diabetes (HFmrEF) |  | − 0.176 (0.202) | 0.84 (0.56–1.25) |  |
Diabetes (HFpEF) |  | − 0.077 (0.190) | 0.93 (0.64–1.34) |  |