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Table 1 Baseline characteristics of postmenopausal women from the NHSI and NHSII

From: Plasma sex hormones and risk of conventional and serrated precursors of colorectal cancer in postmenopausal women

Variablea Non-polyp Conventional adenoma Serrated polyp
No. of participants 4576 535 402
Age at blood draw, years 58.9 (6.1) 59.4 (5.8) 57.5 (6.1)
White, % 99 99 99
Height, cm 164.0 (6.1) 164.6 (5.9) 164.4 (5.0)
Body mass indexb, kg/m2 25.3 (4.5) 25.9 (4.0) 26.1 (4.1)
Family history of colorectal cancer, % 27 34 29
Pack-year of smoking 11.7 (18.0) 15.1 (18.8) 17.8 (18.5)
 Never, % 46 44 34
 Past, % 44 43 47
 Current, % 10 14 20
Alcohol intakeb, g/day 6.1 (9.6) 6.3 (8.5) 6.4 (8.8)
Physical activityb, c, MET-hours/week 19.1 (19.7) 18.7 (19.3) 17.7 (16.5)
AHEI dietary scoreb 54.7 (10.2) 53.4 (9.1) 53.3 (8.9)
Regular aspirin used, % 52 53 49
Biomarkere
 Estrone (pg/ml) 24.40 (17.10–35.19) 25.23 (19.11–37.22) 25.31 (18.47–38.71)
 Total estradiol (pg/ml) 5.79 (4.06–9.42) 6.02 (4.39–10.58) 6.64 (4.33–11.38)
 Free estradiol (pg/ml) 0.08 (0.05–0.13) 0.09 (0.05–0.15) 0.09 (0.05–0.15)
 Total testosterone (ng/dl) 18.70 (13.47–25.76) 18.22 (12.93–25.07) 18.09 (13.27–25.85)
 Free testosterone (ng/dl) 0.13 (0.08–0.20) 0.14 (0.10–0.23) 0.14 (0.10–0.22)
 SHBG (nmol/L) 71.72 (47.57–113.38) 60.70 (40.90–92.75) 60.21 (41.12–93.69)
 Total estradiol (pg/ml)/total testosterone (pg/ml) 0.03 (0.02–0.05) 0.03 (0.02–0.06) 0.04 (0.02–0.06)
  1. Abbreviations: NHS the Nurses’ Health Study, MET metabolic equivalent task, AHEI Alternative Healthy Eating Index, SHBG sex hormone-binding globulin
  2. aAll variables are standardized by age at blood draw except age. Mean (SD) is presented for continuous variables and percentage for categorical variables, unless otherwise specified
  3. bThe average calculated using the two adjacent questionnaires most proximate to blood draw
  4. cPhysical activity is represented by the product sum of the METS of each specific recreational activity and hours spent on that activity per week
  5. dA standard tablet contains 325 mg aspirin and regular users were defined as those who used at least two tablets per week
  6. eThe natural-log transformed biomarker concentrations were back transformed and presented as median values (quartiles). Free estradiol and free testosterone were calculated using a validated algorithm based on total estradiol or total testosterone, SHBG, an assumed constant representing the normal albumin concentration, and the association constants for the binding of estradiol and testosterone to SHBG and albumin
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