Fig. 4
The regulatory network of circRNA-miRNA-mRNA in AML. a This network consists of hsa_circ_0075451, 10 miRNAs, and 84 genes. In this network, red labels represent upregulated genes in the patients with high expression of hsa_circ_0075451, and blue ones represent downregulated miRNAs. Gray lines represent the protein and protein interactive relationship of the encoding genes, purple lines represent miRNAs interacting with genes, and lines represent hsa_circ_0075451 sponging miRNAs, and bold purple lines represent 8 miRNAs’ loss of ability to inhibit expression of PRDM16. b Correlation relationship of the expression of hsa_circ_0075451 and PRDM16 in this study.