Fig. 5
From: EPHA7 mutation as a predictive biomarker for immune checkpoint inhibitors in multiple cancers
EPHA7-MUT was associated with enhanced anti-tumor immunity in TCGA cohort. a Violin plot depicting the distribution of TMB, CNA, and NAL in EPHA7-MUT and EPHA7-WT tumors. b Boxplot depicting the infiltration of 22 immune cells in EPHA7-MUT and EPHA7-WT tumors. CIBERSORT was used to calculate the infiltration degree of these immune cells. Gene expression profiles were uploaded to CIBERSORT web portal, and the algorithm was configured with 1000 permutations. CIBERSORT results were recorded in Additional file 5: Table S3. Samples with deconvolution P value ≥ 0.05 were excluded (n = 2967) (Mann-Whitney U test; ns, not significant; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). c Boxplot depicting the expression level of immune-related genes in EPHA7-MUT and EPHA7-WT groups (Mann-Whitney U test; ns, not significant; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). d Heatmap depicting the log2-transformed fold change in the expression level of immune-related genes across multiple cancer types (EPHA7-MUT vs EPHA7-WT). Blue indicated downregulation and red indicated upregulation