Fig. 6
From: EPHA7 mutation as a predictive biomarker for immune checkpoint inhibitors in multiple cancers
Pathway enrichment analysis in TCGA dataset and possible tumor immune microenvironment in EPHA7-MUT and EPHA7-WT tumors. a Differences in pathway activities scored by GSEA between EPHA7-MUT and EPHA7-WT tumors in TCGA dataset. Significant results (P < 0.05 and FDR < 0.25) of enrichment analysis were summarized in Additional file 6: Table S4. Pathways which might potentially impact the tumor immune microenvironment were presented in a. These pathways were divided into four groups: immune function (blue), intercellular signaling (brown), metabolism (green), and other biological functions (gray). b GSEA plot depicting representative pathways identified by GSEA between EPHA-MUT and EPHA7-WT tumors, including metabolism, cell communication, immune response, and angiogenesis. c Comparison of possible tumor immune microenvironment between EPHA7-MUT and EPHA7-WT tumors. APCs, antigen presenting cells; NK cell, nature killer cell; ECM, extracellular matrix