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Table 3 Risk factors for reinfection: multivariable analysis with pfmdr1. Data from 1934 individuals in the AS-AQ trial arms and 1655 in the AL trial arms were analyzed using accelerated failure-time analysis. Regression coefficients are the ratio of time to reinfection, such that a coefficient > 1 indicates a longer time to reinfection. Covariates significantly associated with reinfection time after adjusting for EIR (p < 0.05) were included in the final model. The prevalence of pfcrt 76T also had a significant effect in a multivariable model with the same covariates (Additional file 1: Table S1) but could not be included in the same model with pfmdr1 86Y due to strong correlation between the two variables. Models assume a lognormal time to reinfection and random site effects

From: The duration of chemoprophylaxis against malaria after treatment with artesunate-amodiaquine and artemether-lumefantrine and the effects of pfmdr1 86Y and pfcrt 76T: a meta-analysis of individual patient data

Covariate (unit)AL multivariable model (N = 1655)
EIR, age, dose, pfmdr1 86Y
AS-AQ multivariable model (N = 1934)
EIR, age, pfmdr1 86Y
Coefficient [ratio of reinfection times] (95% CI)p valueCoefficient [ratio of reinfection times] (95% CI)p value
Loge annual EIR0.81 (0.74, 0.90)< 0.0010.81 (0.75, 0.87)< 0.001
Age (polynomial, years, > 20 grouped together) < 0.001 < 0.001
 age1.01 (0.93, 1.09) 0.94 (0.88, 1.00) 
 (age)21.00 (0.99, 1.02) 1.01 (1.00, 1.02) 
 (age)31.0001 (0.9992, 1.0009) 0.9998 (0.9993, 1.0003) 
Lumefantrine dose (per 10 mg per kg increase) (AL arms only)1.03 (1.01, 1.06)0.002
pfmdr1 86Y prevalence (per 10% increase)1.04 (1.00, 1.09)0.0590.97 (0.94, 0.99)0.012