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Table 2 Summary of laboratory data

From: C-reactive protein as a potential biomarker for disease progression in dengue: a multi-country observational study

Characteristic

n

OFI (N = 394)

n

All dengue patients (N = 1117)

n

Uncomplicated dengue (N = 836)

n

Intermediate dengue (N = 243)

n

Severe dengue (N = 38)

At enrollment

 CRP (mg/L)

394

31.3 (10.2, 88.8)

1117

30.2 (12.4, 61.5)

836

28.6 (10.5, 58.9)

243

35.3 (17.9, 71.8)

38

26.2 (14.1, 71.1)

 Viremia level (× 106 copies/mL)

–

–

1050

35.5 (3.1, 269.6)

783

25.2 (2.0, 185.4)

231

92.9 (7.5, 690.5)

36

128.5 (33.1, 331.2)

 AST (UI/L)

394

30.0 (23.0, 40.0)

1109

43.0 (30.0, 67.0)

831

42.0 (30.0, 62.0)

240

52.0 (33.0, 92.2)

38

60.0 (43.0, 84.8)

 ALT (UI/L)

394

18.0 (13.0, 30.0)

1113

28.0 (18.0, 49.0)

834

27.0 (17.0, 46.0)

241

32.0 (21.0, 67.0)

38

29.0 (18.2, 41.2)

 Albumin (g/L)

394

45.5 (43.5, 47.5)

1105

45.0 (42.5, 47.1)

828

45.0 (42.7, 47.3)

239

44.3 (41.9, 46.9)

38

44.9 (42.6, 47.3)

 Creatine kinase (UI/L)

394

92.5 (70.2, 129.0)

1012

105.0 (77.8, 156.2)

763

104.0 (76.0, 149.0)

221

115.0 (83.0, 171.0)

28

138.0 (91.0, 270.0)

 WBC (× 109/mL)

394

7.7 (5.5, 10.8)

1113

4.3 (3.2, 6.0)

834

4.3 (3.2, 6.0)

241

4.4 (3.1, 6.0)

38

4.0 (2.8, 4.9)

 Neutrophils (%)

394

71.0 (61.5, 79.0)

1108

67.5 (58.0, 75.2)

830

66.3 (57.0, 74.8)

240

70.0 (61.4, 78.0)

38

72.8 (60.3, 77.9)

 Lymphocytes (%)

394

16.5 (11.5, 24.1)

1109

18.6 (11.8, 26.9)

831

18.9 (12.4, 27.4)

240

16.9 (10.9, 24.4)

38

19.8 (11.8, 31.3)

Other time points

 Max HCT change* (%)

360

2.4 (− 1.5, 5.8)

1112

7.1 (2.4, 13.7)

832

5.4 (1.7, 9.9)

243

20.5 (8.6, 24.5)

37

16.7 (6.1, 28.2)

 Platelet nadir (× 109/mL)

383

178 (143, 225)

1113

72.0 (40.0, 119.0)

834

89 (52, 127)

242

40.5 (22.0, 71.0)

37

18 (13, 30)

 CRP at follow-up (mg/L)

30

1.4 (0.5, 4.1)

896

0.8 (0.4, 2.0)

668

0.8 (0.3, 2.0)

196

0.8 (0.4, 2.0)

32

0.8 (0.5, 2.2)

  1. Summary statistics are median (interquartile range)
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, CRP C-reactive protein, DOI day of illness, HCT hematocrit, OFI other febrile illnesses, WBC white blood cell
  3. *Maximum HCT change was calculated by maximum HCT level at the acute phase (DOI 4 to 7) minus baseline HCT, then divided by baseline HCT. Baseline HCT was the minimum HCT level within DOI 1 to 3
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