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Table 2 Summary of laboratory data

From: C-reactive protein as a potential biomarker for disease progression in dengue: a multi-country observational study

CharacteristicnOFI (N = 394)nAll dengue patients (N = 1117)nUncomplicated dengue (N = 836)nIntermediate dengue (N = 243)nSevere dengue (N = 38)
At enrollment
 CRP (mg/L)39431.3 (10.2, 88.8)111730.2 (12.4, 61.5)83628.6 (10.5, 58.9)24335.3 (17.9, 71.8)3826.2 (14.1, 71.1)
 Viremia level (× 106 copies/mL)105035.5 (3.1, 269.6)78325.2 (2.0, 185.4)23192.9 (7.5, 690.5)36128.5 (33.1, 331.2)
 AST (UI/L)39430.0 (23.0, 40.0)110943.0 (30.0, 67.0)83142.0 (30.0, 62.0)24052.0 (33.0, 92.2)3860.0 (43.0, 84.8)
 ALT (UI/L)39418.0 (13.0, 30.0)111328.0 (18.0, 49.0)83427.0 (17.0, 46.0)24132.0 (21.0, 67.0)3829.0 (18.2, 41.2)
 Albumin (g/L)39445.5 (43.5, 47.5)110545.0 (42.5, 47.1)82845.0 (42.7, 47.3)23944.3 (41.9, 46.9)3844.9 (42.6, 47.3)
 Creatine kinase (UI/L)39492.5 (70.2, 129.0)1012105.0 (77.8, 156.2)763104.0 (76.0, 149.0)221115.0 (83.0, 171.0)28138.0 (91.0, 270.0)
 WBC (× 109/mL)3947.7 (5.5, 10.8)11134.3 (3.2, 6.0)8344.3 (3.2, 6.0)2414.4 (3.1, 6.0)384.0 (2.8, 4.9)
 Neutrophils (%)39471.0 (61.5, 79.0)110867.5 (58.0, 75.2)83066.3 (57.0, 74.8)24070.0 (61.4, 78.0)3872.8 (60.3, 77.9)
 Lymphocytes (%)39416.5 (11.5, 24.1)110918.6 (11.8, 26.9)83118.9 (12.4, 27.4)24016.9 (10.9, 24.4)3819.8 (11.8, 31.3)
Other time points
 Max HCT change* (%)3602.4 (− 1.5, 5.8)11127.1 (2.4, 13.7)8325.4 (1.7, 9.9)24320.5 (8.6, 24.5)3716.7 (6.1, 28.2)
 Platelet nadir (× 109/mL)383178 (143, 225)111372.0 (40.0, 119.0)83489 (52, 127)24240.5 (22.0, 71.0)3718 (13, 30)
 CRP at follow-up (mg/L)301.4 (0.5, 4.1)8960.8 (0.4, 2.0)6680.8 (0.3, 2.0)1960.8 (0.4, 2.0)320.8 (0.5, 2.2)
  1. Summary statistics are median (interquartile range)
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, CRP C-reactive protein, DOI day of illness, HCT hematocrit, OFI other febrile illnesses, WBC white blood cell
  3. *Maximum HCT change was calculated by maximum HCT level at the acute phase (DOI 4 to 7) minus baseline HCT, then divided by baseline HCT. Baseline HCT was the minimum HCT level within DOI 1 to 3