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Table 4 IRRs of infection-related hospital admissions in months 3–6 after stratified by the level of propensity and quintile of prior antibiotic use

From: The effectiveness of frequent antibiotic use in reducing the risk of infection-related hospital admissions: results from two large population-based cohorts

 

Propensity for lowest prior antibiotic use

Low

Middle

High

Low

Middle

High

% in groups#

% in groups#

% in groups#

IRR (95% CI)&

IRR (95% CI)&

IRR (95% CI)&

Quintiles of prior antibiotic use

 CPRD

  Low vs lowest

41.4% vs 29.4%

33.5% vs 32.8%

25.1% vs 37.8%

1.21 (1.02–1.45)

1.34 (1.00–1.79)

1.15 (0.75–1.75)

  Middle vs lowest

45.8% vs 25.4%

33.4% vs 32.7%

20.8% vs 41.9%

1.38 (1.18–1.61)

1.38 (1.09–1.75)

1.33 (0.91–1.94)

  High vs lowest

53.7% vs 21.3%

32.5% vs 33.3%

13.8% vs 45.4%

1.75 (1.48–2.06)

1.74 (1.38–2.19)

2.52 (1.45–4.37)

  Highest vs lowest

69.1% vs 16.6%

25.7% vs 36.3%

5.2% vs 47.1%

2.17 (1.79–2.64)

2.88 (2.04–4.07)

5.72 (2.08–15.76)

 SAIL

  Low vs lowest

41.7% vs 27.7%

33.5% vs 32.6%

24.8% vs 39.7%

1.22 (1.06–1.41)

1.42 (1.19–1.69)

1.56 (1.18–2.07)

  Middle vs lowest

50.5% vs 25.3%

32.3% vs 33.4%

17.2% vs 41.4%

1.50 (1.29–1.74)

1.83 (1.44–2.34)

1.82 (1.28–2.59)

  High vs lowest

57.5% vs 21.5%

30.5% vs 34.3%

12.0% vs 44.2%

1.72 (1.47–2.02)

2.62 (2.12–3.24)

3.67 (2.51–5.35)

  Highest vs lowest

69.3% vs 15.8%

25.2% vs 37.1%

5.6% vs 47.2%

2.13 (1.74–2.61)

3.27 (2.60–4.12)

3.01 (1.69–5.37)

  1. #Unmatched cohorts
  2. &Propensity-matched cohorts