Genome-wide genetic links between amyotrophic lateral sclerosis and autoimmune diseases

Table 1 Shared risk loci between ALS and autoimmune disorders

SNP	Genomic position (GRCh37)	Closest gene	FDR value	Associated phenotype	Original ALS P value	Replication ALS P value
rs3828599	5:150401796	GPX3	0.002	CeD	8.08E−08	1.22E−07
rs6456785	6:27390399	ZNF184	0.030	T1D	1.23E−04	4.47E−03
rs3849943	9:27543382	C9orf72	0.037	T1D	3.77E−30	2.73E−23
rs61880881	11:22270782	ANO5	0.015	MS	2.73E−06	n.a.
rs848132	12:111989979	ATXN2	0.031	T1D	1.12E−04	2.14E−02
rs7154847	14:31059969	G2E3	0.027	IBD	4.46E−07	1.98E−06
rs6571361	14:31183168	SCFD1	0.035	IBD	2.54E−07	1.12E−06
rs10138217	14:92497990	TRIP11	0.022	MS	1.07E−06	5.26E−05
rs978220	14:92558135	ATXN3	0.039	MS	1.66E−06	2.24E−05
rs2076756	16:50756881	NOD2	2.44E−04	CD	1.28E−04	n.a.
rs9903355	17:34937221	GGNBP2	0.022	MS	2.14E−06	1.01E−06
rs56185963	20:48514826	SLC9A8	0.024	MS	8.96E−06	4.53E−04
rs68069258	22:50748930	DENND6B	0.026	MS	6.00E−06	n.a.

SNP single-nucleotide polymorphism, A1 effect allele, FDR false discovery rate, n.a. not available, CeD celiac disease, MS multiple sclerosis, T1D type 1 diabetes, IBD inflammatory bowel disease, CD Crohn’s disease

ISSN: 1741-7015