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Table 1 Participant characteristics

From: Serum neurofilament light and tau as prognostic markers for all-cause mortality in the elderly general population—an analysis from the MEMO study

 

All (N = 385)

MRI available (N = 268)

No MRI (N = 117)

Age (years)

73.0 (69.0, 76.0)

72.0 (69.0, 76.0)

74.0 (70.7, 77.0)

Women

182 (47.3)

128 (47.8)

54 (46.2)

Years of education

10.0 (10.0, 11.0)

10.0 (10.0, 11.0)

10.0 (10.0, 11.0)

Body mass index (kg/m2)

27.7 (25.2, 29.8)

27.8 (25.6, 29.8)

27.2 (24.8, 30.1)

Alcohol consumption (g/day)

5.8 (0, 22.9)

5.7 (0, 22.8)

6.0 (0, 23.8)

ADL score (scores 0–10)

0 (0, 1.0)

0 (0, 1.0)

0 (0, 2.0)

Systolic blood pressure (mmHg)

144.0 (133.0, 155.0)

143.0 (132.2, 154.0)

146.0 (135.0, 159.0)

History of arrhythmia

117 (34.4)

74 (31.2)

43 (41.7)

History of brain surgery

6 (1.6)

2 (0.8)

4 (3.5)

History of heart surgery

18 (4.7)

7 (2.6)

11 (9.6)

History of hip replacement

18 (4.7)

11 (4.1)

7 (6.1)

Any comorbidities*

102 (26.5)

61 (22.8)

41 (35.0)

Memory score (z-score)

− 0.1 (− 1.8, 2.0)

0.1 (− 1.6, 2.2)

− 0.7 (− 2.6, 1.4)

Speed score (z-score)

0.6 (− 1.8, 2.4)

0.6 (− 1.4, 2.5)

0.4 (− 2.4, 2.1)

Motor score (z-score)

0.2 (− 1.5, 1.8)

0.5 (− 1.4, 1.8)

− 0.2 (− 1.6, 1.4)

CASCADE score (z-score)

1.1 (− 3.6, 5.1)

1.7 (− 3.3, 5.6)

− 0.6 (− 4.8, 3.2)

Atrophy (scores 0–15)

9.0 (7.0, 10.0)

9.0 (7.0, 10.0)

Subcortical atrophy at the level of the anterior ventricular horns

0.3 (0.3, 0.4)

0.3 (0.3, 0.4)

Total volume WML (mL)

0.3 (0.1, 2.0)

0.3 (0.1, 2.0)

Any lacunar strokes

41 (15.3)

41 (15.3)

Serum NfL (pg/mL)

15.7 (12.1, 20.4)

15.5 (12.2, 19.9)

16.2 (11.7, 20.6)

Serum tau (pg/mL)

0.7 (0.5, 1.0)

0.7 (0.5, 1.0)

0.8 (0.5, 1.0)

  1. Data are medians (25th percentile, 75th percentile) or numbers (percentage)
  2. *Any histories of myocardial infarction, heart failure, vascular surgery, pacemaker, cancer, diabetes, joint replacement, or trauma with loss of function based on medical records