All (N = 385) | MRI available (N = 268) | No MRI (N = 117) | |
---|---|---|---|
Age (years) | 73.0 (69.0, 76.0) | 72.0 (69.0, 76.0) | 74.0 (70.7, 77.0) |
Women | 182 (47.3) | 128 (47.8) | 54 (46.2) |
Years of education | 10.0 (10.0, 11.0) | 10.0 (10.0, 11.0) | 10.0 (10.0, 11.0) |
Body mass index (kg/m2) | 27.7 (25.2, 29.8) | 27.8 (25.6, 29.8) | 27.2 (24.8, 30.1) |
Alcohol consumption (g/day) | 5.8 (0, 22.9) | 5.7 (0, 22.8) | 6.0 (0, 23.8) |
ADL score (scores 0–10) | 0 (0, 1.0) | 0 (0, 1.0) | 0 (0, 2.0) |
Systolic blood pressure (mmHg) | 144.0 (133.0, 155.0) | 143.0 (132.2, 154.0) | 146.0 (135.0, 159.0) |
History of arrhythmia | 117 (34.4) | 74 (31.2) | 43 (41.7) |
History of brain surgery | 6 (1.6) | 2 (0.8) | 4 (3.5) |
History of heart surgery | 18 (4.7) | 7 (2.6) | 11 (9.6) |
History of hip replacement | 18 (4.7) | 11 (4.1) | 7 (6.1) |
Any comorbidities* | 102 (26.5) | 61 (22.8) | 41 (35.0) |
Memory score (z-score) | − 0.1 (− 1.8, 2.0) | 0.1 (− 1.6, 2.2) | − 0.7 (− 2.6, 1.4) |
Speed score (z-score) | 0.6 (− 1.8, 2.4) | 0.6 (− 1.4, 2.5) | 0.4 (− 2.4, 2.1) |
Motor score (z-score) | 0.2 (− 1.5, 1.8) | 0.5 (− 1.4, 1.8) | − 0.2 (− 1.6, 1.4) |
CASCADE score (z-score) | 1.1 (− 3.6, 5.1) | 1.7 (− 3.3, 5.6) | − 0.6 (− 4.8, 3.2) |
Atrophy (scores 0–15) | 9.0 (7.0, 10.0) | 9.0 (7.0, 10.0) | – |
Subcortical atrophy at the level of the anterior ventricular horns | 0.3 (0.3, 0.4) | 0.3 (0.3, 0.4) | – |
Total volume WML (mL) | 0.3 (0.1, 2.0) | 0.3 (0.1, 2.0) | – |
Any lacunar strokes | 41 (15.3) | 41 (15.3) | – |
Serum NfL (pg/mL) | 15.7 (12.1, 20.4) | 15.5 (12.2, 19.9) | 16.2 (11.7, 20.6) |
Serum tau (pg/mL) | 0.7 (0.5, 1.0) | 0.7 (0.5, 1.0) | 0.8 (0.5, 1.0) |