Fig. 3

Methylomic analysis of the human transferrin gene. DNA methylation data was obtained from 5 control livers and 6 livers from patients with severe alcoholic hepatitis. A differentially methylated region (DMR) including 19 CpG around an annotated CpG island was unbiasedly detected by using Illumina EPIC Infinium methylome chip in the transferrin promoter. The methylation beta values and the length of the DMR and the CpG Island are shown. The genomic region of transferrin gene promoter, located in chromosome 3, was visualized by using the gviz package, with the addition of the following ENCODE genomic tracks: HNF4A ChIP seq and DNAse I hypersensitive, both in HepG2 cells (cohort ii)