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Fig. 5 | BMC Medicine

Fig. 5

From: Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases

Fig. 5

Hepatic transferrin production is regulated by the hepatocyte nuclear factor 4Ī± (HNF4Ī±) axis. a Transferrin mRNA expression was determined in primary hepatocytes that were treated with a carrier only (control) or subjected to TGF Ī²1 (b), IL-1Ī² (c), TNFĪ± (d), IL-6 (e), or the HNF4Ī± antagonist BI6015 (f). The expression of Hnf4Ī±, Sod2, Nfkb1, and Hamp were used as positive controls. In b, d, and f, 5 controls and 6 treated samples were used, whereas 4 controls and 4 treated samples were assessed in c and e. The average expression in control cells was arbitrarily set as 1 and all other levels represent a ratio. Mouse L7 (ribosomal) gene was used as an internal control

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