From: Optimizing antiviral treatment for seasonal influenza in the USA: a mathematical modeling analysis
Outcome | Texas | California | Connecticut | Virginia | ||||
---|---|---|---|---|---|---|---|---|
Model projection (#) | Proportion1 (%) | Model projection (#) | Proportion1 (%) | Model projection (#) | Proportion1 (%) | Model projection (#) | Proportion1 (%) | |
Symptomatic cases | ||||||||
 Influenza symptomatic cases without antiviral treatment2 | 2,301,185 (1044395–4,135,596) |  | 2,902,800 (1347273–5,246,107) |  | 162,568 (52024–391,760) |  | 460,854 (149728–1,046,816) |  |
 Influenza symptomatic cases at baseline2,3 | 2,231,561 (1004289–4,046,681) |  | 2,805,437 (1293191–5,117,997) |  | 154,932 (49132–379,116) |  | 441,098 (141980–1,016,914) |  |
Symptomatic cases averted compared to baseline scenario | ||||||||
 Treating early4 while keeping baseline treatment coverage2 | 65,201 (36977–84,458) | 2.9 (2.1–3.7) | 90,847 (49702–121,703) | 3.2 (2.4–3.8) | 7012 (2599–11,923) | 4.5 (3.1–5.3) | 18,229 (6990–28,306) | 4.1 (2.8–4.9) |
 Treating 20% of infected individuals2 early4 | 116,833 (65688–152,635) | 5.2 (3.8–6.5) | 160,451 (87138–216,869) | 5.7 (4.2–6.7) | 12,543 (4611–21,568) | 8.1 (5.7–9.4) | 32,561 (12372–51,130) | 7.4 (5.0–8.7) |
Hospitalizations | ||||||||
 Hospitalizations without antiviral treatment 2 | 9896 (4365–18,385) |  | 13,998 (6298–26,222) |  | 902 (208–2261) |  | 2297 (723–5546) |  |
 Hospitalizations at baseline2,3 | 9301 (4069–17,431) |  | 13,110 (5860–24,783) |  | 833 (256–2119) |  | 2130 (665–5123) |  |
Hospitalizations averted compared to baseline scenario | ||||||||
 Treating early4 while keeping baseline treatment coverage2 | 513 (253–822) | 5.5 (4.7–6.2) | 764 (374–1243) | 5.8 (5.0–6.4) | 59 (20–123) | 7.1 (5.8–7.8) | 143 (49–279) | 6.7 (5.4–7.4) |
 Treating 20% of infected individuals2 early4 | 1021 (494–1686) | 11.0 (9.7–12.1) | 1506 (725–2522) | 11.5 (10.2–12.4) | 115 (38–247) | 13.8 (11.7–14.9) | 279 (95–564) | 13.1 (11.0–14.2) |